Featured Research

from universities, journals, and other organizations

Stem cells a soft touch for nano-engineered biomaterials

Date:
June 9, 2014
Source:
Queen Mary, University of London
Summary:
Stem cell behavior can be modified by manipulating the nanoscale properties of the material they are grown on -- improving the potential of regenerative medicine and tissue engineering as a result, researchers report. In this study, the researchers used tiny material patches known as nanopatches to alter the surface of the substrate and mimic the properties of a softer material.

Scientists from Queen Mary University of London have shown that stem cell behaviour can be modified by manipulating the nanoscale properties of the material they are grown on -- improving the potential of regenerative medicine and tissue engineering as a result.

Related Articles


Stem cells are special because they are essential to the normal function of our organs and tissues. Previous research shows stem cells grown on hard substrates go on to multiply but do not differentiate: a process by which the cells specialize to perform specific functions in the body. In contrast, stem cells grown on softer surfaces do go on to differentiate.

In this new study, published in the journal Nano Letters, the researchers used tiny material patches known as nanopatches to alter the surface of the substrate and mimic the properties of a softer material.

"By changing the surface properties like the shape of the substrate at the nanoscale level, we tricked the stem cells to behave differently," explains co-author Dr Julien Gautrot, from QMUL's School of Engineering and Materials Science and the Institute of Bioengineering.

The team tested different sizes of nanopatches -- from 3 microns to 100 nanometres (about one thousandth of the diameter of a hair). The stem cells behaved as if they were on a soft surface when in contact with the smallest patches because they can't firmly grip them.

Dr Gautrot added: "This development will be useful when there's a need to create a rigid implant to be inserted into the body. Potentially, such nanopatches could provide a soft touch to the surface of the implant so that cells from the neighbouring tissues are not perturbed by such a hard material."


Story Source:

The above story is based on materials provided by Queen Mary, University of London. Note: Materials may be edited for content and length.


Journal Reference:

  1. Julien Ezra Gautrot, Jenny Malmstrφm, Maria Sundh, Coert Margadant, Arnoud Sonnenberg, Duncan Stewart Sutherland. The Nanoscale Geometrical Maturation of Focal Adhesions Controls Stem Cell Differentiation and Mechano-Transduction. Nano Letters, 2014; 140521045232001 DOI: 10.1021/nl501248y

Cite This Page:

Queen Mary, University of London. "Stem cells a soft touch for nano-engineered biomaterials." ScienceDaily. ScienceDaily, 9 June 2014. <www.sciencedaily.com/releases/2014/06/140609122050.htm>.
Queen Mary, University of London. (2014, June 9). Stem cells a soft touch for nano-engineered biomaterials. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2014/06/140609122050.htm
Queen Mary, University of London. "Stem cells a soft touch for nano-engineered biomaterials." ScienceDaily. www.sciencedaily.com/releases/2014/06/140609122050.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins