Featured Research

from universities, journals, and other organizations

Wasp venom used in new therapy for breast cancer

Date:
August 5, 2014
Source:
Plataforma SINC
Summary:
Despite there currently being a wide variety of compounds against cancer, they all have serious side effects. Furthermore, tumors are capable of becoming resistant, limiting this type of treatment. In order to counteract these two disadvantages, scientists have designed a new therapy based on a peptide - the binding of several amino acids - from wasp venom for its potential use against breast cancer.

Wasp. Scientists from the Institute for Biomedical Research (IRB Barcelona) have designed a new therapy based on a peptide -- the binding of several amino acids -- from wasp venom for its potential use against breast cancer.
Credit: Ferrαn Pestaρa

Scientists from the Institute for Biomedical Research (IRB Barcelona) have carried out successful in vitro tests using wasp venom to kill tumour cells. The next step will be to test its efficacy in mouse models.

Related Articles


Despite there currently being a wide variety of compounds against cancer, they all have serious side effects. Furthermore, tumours are capable of becoming resistant, limiting this type of treatment. In order to counteract these two disadvantages, scientists from the Institute for Biomedical Research (IRB Barcelona) have designed a new therapy based on a peptide -- the binding of several amino acids -- from wasp venom for its potential use against breast cancer.

"This peptide has the ability to form pores in the cell plasma membrane, penetrate into the cell and finally, cause its death, either by necrosis or by triggering apoptosis, programmed cell death," Miguel Moreno, lead author of IRB Barcelona explained to Sinc.

However, this powerful 'natural weapon' could not be used due to its high toxicity and lack of cell specificity; that is, it would not only damage tumour cells but would also affect healthy patient cells. As such, the researchers designed a means of transporting the peptide to the tumour and making it accumulate in a specific and controlled manner.

The system consists of a decorated carrier polymer with two components: a peptide that is bound to a tumour cell receptor and the cytotoxic peptide of the wasp venom.

In vitro experiments show that the substance is adequately distributed within the tumour cells and causes their death, while healthy cells, such as red blood cells, are not affected.

Although the results, which have been published in the Journal of Controlled Release, seem to be promising, they are still in their very early stages. The next step is to test their efficacy through in vivo tests in mice. The authors are very optimistic that the research will be successful and this anti-tumour system may be used in the future as a supplementary therapy to those already in existence.

Cancer, a challenge for scientists

Cancer is one of the main causes of death worldwide. For experts, epidemiological trends continue to be alarming given the increases in the rates of incidence and mortality. Nowadays, tumours are treated with radiotherapy, surgery and chemotherapy. The side effects derived from anti-tumour compounds are a result of their low specificity.


Story Source:

The above story is based on materials provided by Plataforma SINC. Note: Materials may be edited for content and length.


Journal Reference:

  1. Miguel Moreno, Esther Zurita, Ernest Giralt. Delivering wasp venom for cancer therapy. Journal of Controlled Release, 2014; 182: 13 DOI: 10.1016/j.jconrel.2014.03.005

Cite This Page:

Plataforma SINC. "Wasp venom used in new therapy for breast cancer." ScienceDaily. ScienceDaily, 5 August 2014. <www.sciencedaily.com/releases/2014/08/140805090951.htm>.
Plataforma SINC. (2014, August 5). Wasp venom used in new therapy for breast cancer. ScienceDaily. Retrieved April 24, 2015 from www.sciencedaily.com/releases/2014/08/140805090951.htm
Plataforma SINC. "Wasp venom used in new therapy for breast cancer." ScienceDaily. www.sciencedaily.com/releases/2014/08/140805090951.htm (accessed April 24, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, April 24, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

85 Killed in Niger by Meningitis Since Start of Year

85 Killed in Niger by Meningitis Since Start of Year

AFP (Apr. 24, 2015) — A meningitis outbreak in Niger has killed 85 people since the start of the year prompting authorities to close schools in the capital Niamey until Monday. Video provided by AFP
Powered by NewsLook.com
Anti-Malaria Jab Hope

Anti-Malaria Jab Hope

Reuters - News Video Online (Apr. 24, 2015) — The world&apos;s first anti-malaria vaccine could get the go-ahead for use in Africa from October if approved by international regulators. Paul Chapman reports. Video provided by Reuters
Powered by NewsLook.com
3D Food Printing: The Meal of the Future?

3D Food Printing: The Meal of the Future?

AP (Apr. 23, 2015) — Developers of 3D food printing hope the culinary technology will revolutionize the way we cook and eat. (April 23) Video provided by AP
Powered by NewsLook.com
Your Genes Could Influence How Much Mosquitoes Love You

Your Genes Could Influence How Much Mosquitoes Love You

Newsy (Apr. 23, 2015) — New research suggests genetics play a big part in how appetizing you smell to mosquitoes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins