Science News
from research organizations

Breast Cancer-causing Gene Predicts Shorter Survival

Date:
January 10, 2006
Source:
Journal of Clinical Investigation
Summary:
In a study appearing in the January 4, 2006 issue of the Journal of Clinical Investigation, Vincent Cryns and colleagues at Northwestern University report how the protein alpha-basic-crystallin, which is commonly expressed in a subtype of breast cancer tumors, is predictive of poor survival in breast cancer patients, independently of other prognostic markers, and also how this protein triggers tumor development. These results may facilitate the development of tailored anti-cancer therapies.
Share:
FULL STORY

In the last 5 years researchers have been examining the genes expressed during breast cancer in order to classify those genes into groups that can reliably predict the outcome of disease. In many cases, exactly how genes with prognostic significance figure into the disease process is not well understood.

In a study appearing in the January 4, 2006 issue of the Journal of Clinical Investigation, Vincent Cryns and colleagues at Northwestern University report how the protein alpha-basic–crystallin, which is commonly expressed in a subtype of breast cancer tumors, is predictive of poor survival in breast cancer patients, independently of other prognostic markers, and also how this protein triggers tumor development.

They reveal that alpha-basic–crystallin is overexpressed in mammary epithelial cells and causes dysregulated growth, changes in cell structure, diminished programmed cell death, and the formation of invasive carcinomas that is linked to activation of the ERK/MAPK signaling pathway. These results may facilitate the development of tailored therapies that are active against this signaling pathway. Ramon Parsons from Columbia University discusses the significance of the this study in an accompanying commentary in the same issue.

###

TITLE: AlphaB-Crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer

View the PDF of this article at: https://www.the-jci.org/article.php?id=25888

ACCOMPANYING COMMENTARY:

TITLE: Is the small heat shock protein alphaB-crystallin an oncogene? AUTHOR CONTACT:

View the PDF of this article at: https://www.the-jci.org/article.php?id=27462


Story Source:

Materials provided by Journal of Clinical Investigation. Note: Content may be edited for style and length.


Cite This Page:

Journal of Clinical Investigation. "Breast Cancer-causing Gene Predicts Shorter Survival." ScienceDaily. ScienceDaily, 10 January 2006. <www.sciencedaily.com/releases/2006/01/060110013649.htm>.
Journal of Clinical Investigation. (2006, January 10). Breast Cancer-causing Gene Predicts Shorter Survival. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2006/01/060110013649.htm
Journal of Clinical Investigation. "Breast Cancer-causing Gene Predicts Shorter Survival." ScienceDaily. www.sciencedaily.com/releases/2006/01/060110013649.htm (accessed May 23, 2017).

RELATED STORIES