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Cell Death By Necrosis Leads To Heart Failure

Date:
August 12, 2007
Source:
Journal of Clinical Investigation
Summary:
The prevalence of heart failure continues to increase in the Western world, making it one of the biggest killers in this region. It is characterized by loss of the muscle cells of the heart (cardiomyocytes). Although this loss is generally considered to occur mostly through a process known as apoptotic cell death, a new study indicates that cell death by necrosis also has a role in the cardiomyocyte loss that accompanies heart failure in mice.
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The prevalence of heart failure continues to increase in the Western world, making it one of the biggest killers in this region. It is characterized by loss of the muscle cells of the heart (cardiomyocytes). Although this loss is generally considered to occur mostly through a process known as apoptotic cell death, a new study  indicates that cell death by necrosis also has a role in the cardiomyocyte loss that accompanies heart failure in mice.

In the study, Jeffery Molkentin and colleagues from Cincinnati Children's Hospital Medical Center, show that in mice increased Ca2+ influx in cardiomyocytes causes the cells to die by necrosis and the mice to die of heart failure. Necrotic cell death and heart failure were enhanced by agonists of beta-adrenergic receptors and abrogated by inhibitors of beta-adrenergic receptors. They were also abrogated in mice lacking cyclophilin D, which is the regulator of the mitochondrial permeability pore.

This demonstration that Ca2+- and mitochondrial-dependent necrotic cardiomyocyte death is a cellular event that contributes to heart failure in mice, led the authors to conclude that heart failure is a pleiotropic disease that involves both apoptotic and necrotic cardiomyocyte death.

The study "Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure" was published online on August 9, in advance of publication in the September print issue of the Journal of Clinical Investigation.


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Journal of Clinical Investigation. "Cell Death By Necrosis Leads To Heart Failure." ScienceDaily. ScienceDaily, 12 August 2007. <www.sciencedaily.com/releases/2007/08/070810211434.htm>.
Journal of Clinical Investigation. (2007, August 12). Cell Death By Necrosis Leads To Heart Failure. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2007/08/070810211434.htm
Journal of Clinical Investigation. "Cell Death By Necrosis Leads To Heart Failure." ScienceDaily. www.sciencedaily.com/releases/2007/08/070810211434.htm (accessed May 26, 2017).

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