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Diabetes Drugs' Potential Adverse Side Effect Explained

Date:
September 13, 2007
Source:
Journal of Clinical Investigation
Summary:
Drugs that are agonists of the receptor PPAR-gamma are used to treat individuals with diabetes. However, it has been suggested that their use is associated with a slightly increased risk of heart failure. A potential explanation for this adverse effect that is observed in a minority of patients is outlined in a new study.
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Drugs that are agonists of the receptor PPAR-gamma are used to treat individuals with diabetes. However, it has been suggested that their use is associated with a slightly increased risk of heart failure.

In a new study, Ira Goldberg and colleagues at Columbia University, New York, outline a potential explanation for the adverse effects observed in a minority of patients being treated with PPAR-gamma agonists.

To directly determine the effects of increased PPAR-gamma activity in the heart, the authors generated mice expressing increased amounts of PPAR-gamma in the heart compared with normal mice.

Fat and carbohydrates accumulated in the heart muscle cells of these mice causing a deterioration in heart function (a process known as glucolipotoxicity). Administration of a PPAR-gamma agonist to these mice exacerbated their heart dysfunction. The authors therefore conclude that the adverse effect of PPAR-gamma agonists on heart function in humans might be due to glucolipotoxocity.

Article:  Cardiomyocyte expression of PPAR-gamma leads to cardiac dysfunction in mice


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Journal of Clinical Investigation. "Diabetes Drugs' Potential Adverse Side Effect Explained." ScienceDaily. ScienceDaily, 13 September 2007. <www.sciencedaily.com/releases/2007/09/070906214958.htm>.
Journal of Clinical Investigation. (2007, September 13). Diabetes Drugs' Potential Adverse Side Effect Explained. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2007/09/070906214958.htm
Journal of Clinical Investigation. "Diabetes Drugs' Potential Adverse Side Effect Explained." ScienceDaily. www.sciencedaily.com/releases/2007/09/070906214958.htm (accessed May 23, 2017).

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