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Over-utilization of intravenous proton pump inhibitor in non-intensive care unit patients

Date:
March 5, 2010
Source:
World Journal of Gastroenterology
Summary:
A research team from Lebanon assessed the appropriateness of the utilization of proton-pump-inhibitors (PPIs) and their associated cost impact in a university hospital. The assessment revealed an over-utilization of PPIs via the intravenous route of administration and for a claimed stress ulcer prophylaxis indication in non-intensive care patients, which resulted in an increased cost burden. The authors recommended the restriction of PPI use for justified and evidence-based indications and route of administration.
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FULL STORY

Proton pump inhibitors (PPIs) are the most effective agents for treating acid related gastrointestinal (GI) disorders. The utilization of intravenous (IV) formulations of PPIs has dramatically increased in health care institutions for inappropriate indications, route of administration and length of treatment. This is associated with an increased cost burden, increased risk of IV related infections, and utilization of hospital resources.

A research team from Lebanon assessed the clinical and cost impacts of PPI utilization in hospitalized patients. Their study was published on February 28, 2010 in the World Journal of Gastroenterology.

Their results illustrated that the majority of non-intensive care patients were receiving PPIs for claimed stress ulcer prophylaxis (SUP); of which, less than half met the guideline criteria for SUP indication or for Non-Steroidal-Anti-inflammatory Drugs (NSAIDs)-induced ulcer prophylaxis, while the remaining patients were identified as having an unjustified indication for PPI use. Regardless of the appropriateness of the initial intravenous route of administration, switching patients to the oral form when deemed appropriate was carried out in only one third of patients.

Furthermore, the cost analysis associated with the inappropriateness of the indication for PPI use as well as the route of administration of PPI revealed an unnecessary increase in cost.

The researchers highlighted the importance of implementing restrictions on the use of intravenous PPI in order to improve not only clinical impact but also cost impact.


Story Source:

Materials provided by World Journal of Gastroenterology. Note: Content may be edited for style and length.


Journal Reference:

  1. Nasser SC, Nassif JG, Dimassi HI. Clinical and cost impact of intravenous proton pump inhibitor use in non-ICU patients. World Journal of Gastroenterology, 2010; 16 (8): 982 DOI: 10.3748/wjg.v16.i8.982

Cite This Page:

World Journal of Gastroenterology. "Over-utilization of intravenous proton pump inhibitor in non-intensive care unit patients." ScienceDaily. ScienceDaily, 5 March 2010. <www.sciencedaily.com/releases/2010/03/100305112209.htm>.
World Journal of Gastroenterology. (2010, March 5). Over-utilization of intravenous proton pump inhibitor in non-intensive care unit patients. ScienceDaily. Retrieved June 25, 2024 from www.sciencedaily.com/releases/2010/03/100305112209.htm
World Journal of Gastroenterology. "Over-utilization of intravenous proton pump inhibitor in non-intensive care unit patients." ScienceDaily. www.sciencedaily.com/releases/2010/03/100305112209.htm (accessed June 25, 2024).

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