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Genetic 'spelling mistakes' that increase risk of common cancers determined
- Date:
- March 27, 2013
- Source:
- Karolinska Institutet
- Summary:
- More than 80 genetic 'spelling mistakes' that can increase the risk of breast, prostate and ovarian cancer have been found in a large, international research study. For the first time, the researchers also have a relatively clear picture of the total number of genetic alterations that can be linked to these cancers.
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More than 80 genetic 'spelling mistakes' that can increase the risk of breast, prostate and ovarian cancer have been found in a large, international research study within the framework of the EU network COGS. For the first time, the researchers also have a relatively clear picture of the total number of genetic alterations that can be linked to these cancers. Ultimately the researchers hope to be able to calculate the individual risk of cancer, to better understand how these cancers develop and to be able to generate new treatments.
Journal References:
- Rosalind A Eeles et al. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nature Genetics, 2013; 45 (4): 385 DOI: 10.1038/ng.2560
- Paul D P Pharoah et al. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nature Genetics, 2013; 45 (4): 362 DOI: 10.1038/ng.2564
- Stig E Bojesen et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nature Genetics, 2013; 45 (4): 371 DOI: 10.1038/ng.2566
- Montserrat Garcia-Closas et al. Genome-wide association studies identify four ER negative–specific breast cancer risk loci. Nature Genetics, 2013; 45 (4): 392 DOI: 10.1038/ng.2561
- Kyriaki Michailidou et al. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nature Genetics, 2013; 45 (4): 353 DOI: 10.1038/ng.2563
Cite This Page:
Karolinska Institutet. "Genetic 'spelling mistakes' that increase risk of common cancers determined." ScienceDaily. ScienceDaily, 27 March 2013. <www.sciencedaily.com
Karolinska Institutet. (2013, March 27). Genetic 'spelling mistakes' that increase risk of common cancers determined. ScienceDaily. Retrieved September 17, 2025 from www.sciencedaily.com
Karolinska Institutet. "Genetic 'spelling mistakes' that increase risk of common cancers determined." ScienceDaily. www.sciencedaily.com
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