New! Sign up for our free email newsletter.
Science News
from research organizations

Omega-3 fatty acids may help heal a broken heart

Date:
May 30, 2013
Source:
Federation of American Societies for Experimental Biology
Summary:
Procedures like angioplasty, stenting and bypass surgery may save lives, but they also cause excessive inflammation and scarring, which ultimately can lead to permanent disability and even death. A new research report shows that naturally derived compounds from polyunsaturated fatty acids (omega-3s) may reduce the inflammation associated with these procedures to help arteries more fully and completely heal.
Share:
FULL STORY

Procedures like angioplasty, stenting and bypass surgery may save lives, but they also cause excessive inflammation and scarring, which ultimately can lead to permanent disability and even death. A new research report appearing in The FASEB Journal, shows that naturally derived compounds from polyunsaturated fatty acids (omega-3s) may reduce the inflammation associated with these procedures to help arteries more fully and completely heal.

"Our study suggests that biologically active, naturally occurring compounds derived from omega-3 PUFAs reduce inflammation and improve the healing of blood vessels after injury," said Michael S. Conte, M.D., a researcher involved in the work from Division of Vascular and Endovascular Surgery and the Heart and Vascular Center at the University of California, in San Francisco, CA. "They suggest a new opportunity to improve the long-term results of cardiovascular procedures such as bypass surgery and angioplasty by the therapeutic application of this class of agents or their dietary precursors."

To make this discovery, Conte and colleagues studied the effects of the compounds (resolvin or RvD) first in cultured vascular cells taken from patients who had undergone bypass operations, and then in rabbits who were treated with a balloon angioplasty procedure in the arteries of the hind limb. In the human cells, treatment with RvD dramatically reduced features that are associated with the typical vascular injury response -- inflammation, cell migration, and cell growth in vascular smooth muscle cells. The potency of these compounds corresponds to concentrations that have been measured in the blood of human subjects taking high dose fish oil supplements for short periods of time. In rabbits, researchers treated the artery with RvD at the time of the balloon angioplasty procedure by infusing the drug directly into the vessel, and found that this one-time treatment reduced inflammation and subsequent scarring of the vessel after one month.

"If successful in further studies, this finding could be a huge benefit to patients undergoing these procedures," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "What's even better, is that these potentially lifesaving compounds are already available in any fish market or grocery store."


Story Source:

Materials provided by Federation of American Societies for Experimental Biology. Note: Content may be edited for style and length.


Journal Reference:

  1. T. Miyahara, S. Runge, A. Chatterjee, M. Chen, G. Mottola, J. M. Fitzgerald, C. N. Serhan, M. S. Conte. D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. The FASEB Journal, 2013; 27 (6): 2220 DOI: 10.1096/fj.12-225615

Cite This Page:

Federation of American Societies for Experimental Biology. "Omega-3 fatty acids may help heal a broken heart." ScienceDaily. ScienceDaily, 30 May 2013. <www.sciencedaily.com/releases/2013/05/130530111155.htm>.
Federation of American Societies for Experimental Biology. (2013, May 30). Omega-3 fatty acids may help heal a broken heart. ScienceDaily. Retrieved May 25, 2024 from www.sciencedaily.com/releases/2013/05/130530111155.htm
Federation of American Societies for Experimental Biology. "Omega-3 fatty acids may help heal a broken heart." ScienceDaily. www.sciencedaily.com/releases/2013/05/130530111155.htm (accessed May 25, 2024).

Explore More

from ScienceDaily

RELATED STORIES