Paracetamol (acetaminophen) is the most commonly used medicine in pregnancy, yet there are very few studies that have investigated the possible long-term consequences for the child. A new study from the Norwegian Institute of Public Health suggests that long-term use of paracetamol during pregnancy may increase the risk of adverse effects on child development.
The study uses data from the Norwegian Mother and Child Cohort Study to investigate the effect of paracetamol during pregnancy on psychomotor development, behaviour and temperament at 3 years of age. Almost 3000 sibling pairs were included in the study.
The study is a collaboration between the University of Oslo, the Norwegian Institute of Public Health and the Hospital for Sick Children in Toronto, Canada, and was published in the International Journal of Epidemiology 25th October 2013.
By comparing children who were exposed to paracetamol during pregnancy with unexposed siblings of the same sex, researchers could control for a variety of genetic and environmental factors, in addition to other important factors such as infections, fever, use of other medications, alcohol intake and smoking.
Need for more research
"The results strengthen our concern that long-term use of paracetamol during pregnancy may have an adverse effect on child development, but that occasional use for short periods is probably not harmful to the fetus. Importantly, we cannot assume that there is a causal relationship between maternal use of paracetamol during pregnancy and adverse effects in children from an epidemiological study. Since this is the only study to show this, there is a need for further research to confirm or refute these results," says Professor Hedvig Nordeng.
Nordeng is a professor at the School of Pharmacy, University of Oslo, and is also affiliated as a researcher at the Division of Mental Health, Norwegian Institute of Public Health.
"The findings support the advice of medical authorities; the first choice for pain is paracetamol, but one should be restrictive with all medicine use in pregnancy," says Nordeng.
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