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Discovery may help breast cancer treatment

Date:
November 7, 2014
Source:
City College of New York
Summary:
A molecule that could lead to developing treatment for one of the most aggressive forms of breast cancer has been identified by researchers. Triple negative breast cancers (TNBCs) have a high mortality rate owing to aggressive proliferation and metastasis and a lack of effective therapeutic options. However a research team has discovered the overexpression of intercellular adhesion molecule-1 (ICAM-1) in human TNBC cell lines and tissues, and demonstrated that it is a potential molecular target and biomarker for TNBC therapy and diagnosis.
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Researchers led by Dr. Debra Auguste, associate professor, biomedical engineering, in the Grove School of Engineering at The City College of New York, have identified a molecule that could lead to developing treatment for one of the most aggressive forms of breast cancer.

Triple negative breast cancers (TNBCs) have a high mortality rate owing to aggressive proliferation and metastasis and a lack of effective therapeutic options. However, Professor Auguste's team, discovered the overexpression of intercellular adhesion molecule-1 (ICAM-1) in human TNBC cell lines and tissues, and demonstrated that it is a potential molecular target and biomarker for TNBC therapy and diagnosis.

"No therapies are available to treat triple negative breast cancer cells and because of that patients have a poor prognosis," said Professor Auguste, the recipient of a 2014 Presidential Early Career Award for Scientists and Engineers.

The Identification of ICAM-1 as a TNBC target and biomarker may lead to the development of a new strategy and platform for addressing a critical gap in TNBC patient care, she added.


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Materials provided by City College of New York. Note: Content may be edited for style and length.


Cite This Page:

City College of New York. "Discovery may help breast cancer treatment." ScienceDaily. ScienceDaily, 7 November 2014. <www.sciencedaily.com/releases/2014/11/141107134941.htm>.
City College of New York. (2014, November 7). Discovery may help breast cancer treatment. ScienceDaily. Retrieved February 29, 2024 from www.sciencedaily.com/releases/2014/11/141107134941.htm
City College of New York. "Discovery may help breast cancer treatment." ScienceDaily. www.sciencedaily.com/releases/2014/11/141107134941.htm (accessed February 29, 2024).

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