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12-year study confirms overall safety of measles vaccines

Date:
January 6, 2015
Source:
Kaiser Permanente
Summary:
A 12-year study of two measles-containing vaccines found that seven main adverse outcomes were unlikely after either vaccine. "This level of safety monitoring for vaccines can give the public confidence that vaccine surveillance is ongoing and that if a safety problem existed, it would be detected," said the first author of the study.
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A 12-year study of two measles-containing vaccines, published today in Pediatrics, found that seven main adverse outcomes were unlikely after either vaccine.

The study, conducted by the Kaiser Permanente Vaccine Study Center, included children aged 12 to 23 months, from January 2000 through June 2012, who received measles-mumps-rubella-varicella (or MMRV) or separately administered, same-day measles-mumps-rubella and varicella (or MMR + V) vaccines. A total of 123,200 MMRV doses and 584,987 MMR + V doses were evaluated.

Comparing MMRV with MMR + V found no increased risk of seven main neurological, blood or immune system disorders (immune thrombocytopenia purpura, anaphylaxis, ataxia, arthritis, meningitis/encephalitis, acute disseminated encephalomyelitis and Kawasaki disease). No new safety concerns were identified after either vaccine, and most outcomes studied were unlikely after either vaccine.

"This study did not identify any new safety concerns comparing MMRV with MMR + V or after either the MMRV or the MMR + V vaccine," said lead author Nicola P. Klein, MD, PhD, co-director of the Vaccine Study Center. "In fact, there were few or zero events for several outcomes following vaccination. These findings indicate that even if an increased risk for these outcomes exists, the risk is low and rare. This should reassure parents that these outcomes are unlikely after either vaccine."

The study also confirmed the findings from previous studies that MMRV and MMR + V are associated with fever and febrile seizure seven to 10 days after vaccination among 1-year-old children, and that MMRV versus MMR + V is associated with an increased risk of seizures during that interval. While febrile seizures are the most common neurologic adverse events following immunization with measles-containing vaccines, the risk is small -- less than one febrile seizure per 1,000 injections. Other previous studies have not found any increased risk for fever or febrile seizures following either vaccine among 4- to 6-year-old children.

"This level of safety monitoring for vaccines can give the public confidence that vaccine surveillance is ongoing and that if a safety problem existed, it would be detected," said Dr. Klein. "Our findings offer reassurance that adverse outcomes of measles-containing vaccines are extremely rare and unlikely, and that parents of 1-year-old children can choose MMR + V instead of MMRV vaccines to reduce the low risk of fever and febrile seizures."


Story Source:

Materials provided by Kaiser Permanente. Note: Content may be edited for style and length.


Journal Reference:

  1. N. P. Klein, E. Lewis, B. Fireman, S. J. Hambidge, A. Naleway, J. C. Nelson, E. A. Belongia, W. K. Yih, J. D. Nordin, R. C. Hechter, E. Weintraub, R. Baxter. Safety of Measles-Containing Vaccines in 1-Year-Old Children. PEDIATRICS, 2015; DOI: 10.1542/peds.2014-1822

Cite This Page:

Kaiser Permanente. "12-year study confirms overall safety of measles vaccines." ScienceDaily. ScienceDaily, 6 January 2015. <www.sciencedaily.com/releases/2015/01/150106095242.htm>.
Kaiser Permanente. (2015, January 6). 12-year study confirms overall safety of measles vaccines. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2015/01/150106095242.htm
Kaiser Permanente. "12-year study confirms overall safety of measles vaccines." ScienceDaily. www.sciencedaily.com/releases/2015/01/150106095242.htm (accessed May 24, 2017).

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