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Fish peptide could help in battle against cardiovascular disease

Date:
January 12, 2015
Source:
University of Leicester
Summary:
A major international review of a peptide originally found in fish that could be used in the battle against cardiovascular disease has been released by scientists. "We have been working on this exciting peptide for a number of years; it exhibits a very interesting pharmacological profile. Design and evaluation of small molecule drugs has potential for use in the treatment of several cardiovascular diseases," said one investigator.
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A major international review of a peptide originally found in fish that could be used in the battle against cardiovascular disease has been published.
 
Professor David Lambert from the University of Leicester’s Department of Cardiovascular Sciences contributed to the review, which has been largely written by the International Union of Basic and Clinical Pharmacology (IUPHAR) subcommittee, to pull together the vast literature on Urotensin II (UII), a peptide first isolated from teleost fish.
 
UII activates a G protein–coupled receptor called UT to modulate a number of signalling pathways including intracellular Calcium. Interestingly, the peptide can constrict some blood vessels yet dilate others.
 
The review, which is published in the high impact journal Pharmacological Reviews, has shown that UII can modulate a vast array of biologic activities encompassing the cardiovascular system, kidneys and central nervous system.
 
Professor Lambert said: “We have been working on this exciting peptide for a number of years; it exhibits a very interesting pharmacological profile. Design and evaluation of small molecule drugs has potential for use in the treatment of several cardiovascular diseases.”


Story Source:

Materials provided by University of Leicester. Note: Content may be edited for style and length.


Journal Reference:

  1. David Vaudry et al. ASPET's Annual Meeting at Experimental Biology 2015, March 28 - April 1, Boston, MA International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, Urotensin II–Related Peptide, and Their Receptor: From Structure to Function. Pharmacological Reviews, January 2015 DOI: 10.1124/pr.114.009480

Cite This Page:

University of Leicester. "Fish peptide could help in battle against cardiovascular disease." ScienceDaily. ScienceDaily, 12 January 2015. <www.sciencedaily.com/releases/2015/01/150112082910.htm>.
University of Leicester. (2015, January 12). Fish peptide could help in battle against cardiovascular disease. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/01/150112082910.htm
University of Leicester. "Fish peptide could help in battle against cardiovascular disease." ScienceDaily. www.sciencedaily.com/releases/2015/01/150112082910.htm (accessed May 23, 2017).

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