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Protein linked to development of asthma

Date:
February 20, 2015
Source:
Medical College of Wisconsin
Summary:
Researchers have linked a specific protein, CCL28, to the development of post-viral infection asthma, which is the first step in generating a novel type of asthma therapy designed to prevent development of post-viral asthma in young children.
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Researchers at the Medical College of Wisconsin (MCW) have linked a specific protein to the development of post-viral infection asthma, which is the first step in generating a novel type of asthma therapy designed to prevent development of post-viral asthma in young children.

The findings are published in the Journal of Biological Chemistry.

Brian F. Volkman, PhD, professor of biochemistry; and Mitchell H. Grayson, MD, associate professor of allergy and immunology; are the lead researchers on the study.

Asthma is a chronic disease of the airways that affects more than 300 million people worldwide. It is the number one illness leading to school absences in children, and accounts for more than 1.8 million emergency room visits annually. There is no cure; all current therapies focus on providing symptomatic relief and reducing the number and severity of attacks.

"Understanding the molecular mechanisms by which asthma develops and establishes itself as a chronic disease is key to elucidating alternative and potentially curative therapies," said Dr. Grayson.

The researchers previously found evidence linking a human chemokine (protein) called CCL28 to the development of chronic asthma. This study is the first, however, that examines structural analysis and its impact on disease development.

"We found that even in the absence of a viral infection, CCL28 can play a role in the induction of asthma pathology--when the protein is natively folded. If unfolded, it does not," explained Dr. Volkman. "We propose that by exploiting the unique structural features of CCL28, potent and specific CCL28 inhibitors may be developed. This work is the first step in generating a novel type of asthma therapy that may have the power to prevent development of post-viral asthma in young children."


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Materials provided by Medical College of Wisconsin. Note: Content may be edited for style and length.


Journal Reference:

  1. Monica A. Thomas, Becky J. Buelow, Amanda M. Nevins, Stephanie E. Jones, Francis C. Peterson, Rebekah L. Gundry, Mitchell H. Grayson, Brian F. Volkman. Structure-Function Analysis of CCL28 in the Development of Post-viral Asthma. Journal of Biological Chemistry, 2015; 290 (7): 4528 DOI: 10.1074/jbc.M114.627786

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Medical College of Wisconsin. "Protein linked to development of asthma." ScienceDaily. ScienceDaily, 20 February 2015. <www.sciencedaily.com/releases/2015/02/150220133344.htm>.
Medical College of Wisconsin. (2015, February 20). Protein linked to development of asthma. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/02/150220133344.htm
Medical College of Wisconsin. "Protein linked to development of asthma." ScienceDaily. www.sciencedaily.com/releases/2015/02/150220133344.htm (accessed May 23, 2017).

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