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Viagra to prevent transmission of the malaria parasite?

Date:
May 7, 2015
Source:
CNRS (Délégation Paris Michel-Ange)
Summary:
By increasing the stiffness of erythrocytes infected by the causal agent of malaria, Viagra favors their elimination from the blood circulation and may therefore reduce transmission of the parasite from humans to mosquitoes. This astonishing discovery could lead to a treatment to reduce the spread of malaria within a population.
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The deformability of gametocyte-infected erythrocytes, facilitated when the cAMP pathway is inhibited, allows them to circulate freely through the spleen and remain accessible to mosquitoes in the blood circulation (top). The action of Viagra increases the stiffness of infected erythrocytes by activating the cAMP pathway, preventing their passage through the spleen endothelium and clearing the parasites from the blood circulation (bottom).
Credit: © Catherine Lavazec

By increasing the stiffness of erythrocytes infected by the causal agent of malaria, Viagra favors their elimination from the blood circulation and may therefore reduce transmission of the parasite from humans to mosquitoes. This astonishing discovery, made by scientists from the CNRS, INSERM, Université Paris Descartes -- at the Institut Cochin -- and the Institut Pasteur, working in collaboration with a team from the London School of Hygiene and Tropical Medicine, could lead to a treatment to reduce the spread of malaria within a population. Their work is published in PLOS Pathogens on 7 May 2015.

Plasmodium falciparum, the parasite that causes malaria, has a complex developmental cycle that is partially completed in humans and partially in the anopheline mosquito. Treatments for malaria target the asexual forms of this parasite that cause symptoms, but not the sexual forms transmitted from a human to a mosquito when it bites. Eradication of this disease thus necessitates the development of new types of treatments against sexual forms of the parasite in order to block transmission and thus prevent dissemination of the disease within the population.

The sexual forms of the parasite develop in human erythrocytes sequestered in the bone marrow before they are released into the blood. They are then accessible to mosquitoes, which can ingest them when they bite (see the top of the image on page 2). But circulating erythrocytes -- whether they are gametocyte-infected or not -- are deformable, thus preventing their clearance via the spleen, which constantly filters the blood and only retains stiff, old or abnormal erythrocytes. However, gametocyte-infected erythrocytes can easily pass through the spleen and persist for several days in the blood circulation.

During a new study, the scientists thus sought to stiffen the infected erythrocytes. They showed that the deformability of gametocyte-infected erythrocytes is regulated by a signaling pathway that involves cAMP. When the cAMP molecules accumulate, the erythrocyte becomes stiffer. cAMP is degraded by the enzyme phosphodiesterase, whose action thus promotes erythrocyte deformability.

Using an in vitro model reproducing filtration by the spleen, the scientists were able to identify several pharmacological agents that inhibit phosophodiesterases and can therefore increase the stiffness of infected erythrocytes. One of these agents is sildenafil citrate, better known under its brand name of Viagra. The authors showed that this agent, used at a standard dose, had the potential to increase the stiffness of sexual forms of the parasite and thus favor the elimination of infected erythrocytes by the spleen.

This discovery could help find new ways to stop the spread of malaria in a population. Modifying the active substance in Viagra to block its erectile effect, or testing similar agents devoid of this adverse effect, could indeed result in a treatment to prevent transmission of the parasite from humans to mosquitoes.


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Materials provided by CNRS (Délégation Paris Michel-Ange). Note: Content may be edited for style and length.


Journal Reference:

  1. Ghania Ramdani, Bernina Naissant, Eloise Thompson, Florence Breil, Audrey Lorthiois, Florian Dupuy, Ross Cummings, Yoann Duffier, Yolanda Corbett, Odile Mercereau-Puijalon, Kenneth Vernick, Donatella Taramelli, David A. Baker, Gordon Langsley, Catherine Lavazec. cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. PLOS Pathogens, 2015; 11 (5): e1004815 DOI: 10.1371/journal.ppat.1004815

Cite This Page:

CNRS (Délégation Paris Michel-Ange). "Viagra to prevent transmission of the malaria parasite?." ScienceDaily. ScienceDaily, 7 May 2015. <www.sciencedaily.com/releases/2015/05/150507153954.htm>.
CNRS (Délégation Paris Michel-Ange). (2015, May 7). Viagra to prevent transmission of the malaria parasite?. ScienceDaily. Retrieved May 25, 2017 from www.sciencedaily.com/releases/2015/05/150507153954.htm
CNRS (Délégation Paris Michel-Ange). "Viagra to prevent transmission of the malaria parasite?." ScienceDaily. www.sciencedaily.com/releases/2015/05/150507153954.htm (accessed May 25, 2017).

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