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Autologous stem cell therapy helpful in traumatic brain injury

Date:
June 5, 2015
Source:
University of Texas Health Science Center at Houston
Summary:
The use of cell therapy after traumatic brain injury in children can reduce the amount of therapeutic interventions needed to treat the patient, as well as the amount of time the child spends in neurointensive care, according to research.
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The use of cell therapy after traumatic brain injury (TBI) in children can reduce the amount of therapeutic interventions needed to treat the patient, as well as the amount of time the child spends in neurointensive care, according to research by The University of Texas Health Science Center at Houston (UTHealth) Medical School.

The study appeared in the most recent issue of Pediatric Critical Care Medicine.

TBI patients at Children's Memorial Hermann Hospital from 2000 to 2008 were divided into two groups: those who received autologous bone marrow stem cells as part of a pilot study and those who did not. Researchers used the Pediatric Intensity Level of Therapy score to determine the degree of therapeutic intensity that was done to reduce the cranial pressure below the danger zone.

For those who received the stem cells, researchers noted a significant reduction in the score beginning at 24 hours post-treatment through the first week. Patients who did not receive the stem cells spent nearly twice as much time in neurointensive care -- 15.6 days compared to 8.2.

"Everything we do to treat traumatic brain injury is aimed at reducing the pressure in the brain," said Charles S. Cox, Jr., M.D., principal investigator, professor and the George and Cynthia Mitchell Distinguished Chair in Neurosciences at UTHealth and co-director of the Texas Trauma Institute at Memorial Hermann-Texas Medical Center. "We can measure the pressure and there are medications to reduce the water in the brain but all of those have risks associated with them, such as renal failure and kidney problems. Our study showed that with stem cell therapy, we need to do less intervention for a shorter period of time for the patient."


Story Source:

Materials provided by University of Texas Health Science Center at Houston. Original written by Deborah Mann Lake. Note: Content may be edited for style and length.


Journal Reference:

  1. George P. Liao, Matthew T. Harting, Robert A. Hetz, Peter A. Walker, Shinil K. Shah, Christopher J. Corkins, Travis G. Hughes, Fernando Jimenez, Steven C. Kosmach, Mary-Clare Day, KuoJen Tsao, Dean A. Lee, Laura L. Worth, James E. Baumgartner, Charles S. Cox. Autologous Bone Marrow Mononuclear Cells Reduce Therapeutic Intensity for Severe Traumatic Brain Injury in Children*. Pediatric Critical Care Medicine, 2015; 16 (3): 245 DOI: 10.1097/PCC.0000000000000324

Cite This Page:

University of Texas Health Science Center at Houston. "Autologous stem cell therapy helpful in traumatic brain injury." ScienceDaily. ScienceDaily, 5 June 2015. <www.sciencedaily.com/releases/2015/06/150605182938.htm>.
University of Texas Health Science Center at Houston. (2015, June 5). Autologous stem cell therapy helpful in traumatic brain injury. ScienceDaily. Retrieved October 5, 2024 from www.sciencedaily.com/releases/2015/06/150605182938.htm
University of Texas Health Science Center at Houston. "Autologous stem cell therapy helpful in traumatic brain injury." ScienceDaily. www.sciencedaily.com/releases/2015/06/150605182938.htm (accessed October 5, 2024).

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