Science News
from research organizations

Programming adult stem cells to treat muscular dystrophy and more by mimicking nature

Date:
July 22, 2015
Source:
American Chemical Society
Summary:
Stem cells hold great potential for addressing a variety of conditions from spinal cord injuries to cancer, but they can be difficult to control. Scientists now report a new way to mimic the body's natural approach to programming these cells. Using this method, they successfully directed adult stem cells to turn specifically into muscle, which could potentially help treat patients with muscular dystrophy.
Share:
FULL STORY

Stem cells hold great potential for addressing a variety of conditions from spinal cord injuries to cancer, but they can be difficult to control. Scientists are now reporting in the journal ACS Nano a new way to mimic the body's natural approach to programming these cells. Using this method, they successfully directed adult stem cells to turn specifically into muscle, which could potentially help treat patients with muscular dystrophy.

In the 1990s, scientists first isolated human embryonic stem cells, which can turn into any kind of cell in the body, and the promise of a new way to treat diseases emerged. Since then, scientists have also discovered adult stem cells in a number of organs in the body, including the brain, lungs and skin, that can turn into a limited number of cell types. However, harnessing these special cells to treat disease has been difficult. One of the main obstacles has been figuring out how to control them. Ki-Bum Lee and colleagues wanted to tackle this challenge.

The researchers created an artificial version of a transcription factor -- a protein critical to orchestrating stem-cell differentiation -- using gold nanoparticles. They added small molecules to mimic the structure and function of the natural transcription factor that induces muscle-cell growth. The synthetic proteins, called NanoScript, successfully coaxed stem cells derived from fat tissue to become muscle. The researchers say they can potentially design their NanoScript system to grow other cell types, too.


Story Source:

Materials provided by American Chemical Society. Note: Content may be edited for style and length.


Journal Reference:

  1. Sahishnu Patel, Perry T. Yin, Hiroshi Sugiyama, Ki-Bum Lee. Inducing Stem Cell Myogenesis Using NanoScript. ACS Nano, 2015; 150629143136005 DOI: 10.1021/acsnano.5b00709

Cite This Page:

American Chemical Society. "Programming adult stem cells to treat muscular dystrophy and more by mimicking nature." ScienceDaily. ScienceDaily, 22 July 2015. <www.sciencedaily.com/releases/2015/07/150722115529.htm>.
American Chemical Society. (2015, July 22). Programming adult stem cells to treat muscular dystrophy and more by mimicking nature. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/07/150722115529.htm
American Chemical Society. "Programming adult stem cells to treat muscular dystrophy and more by mimicking nature." ScienceDaily. www.sciencedaily.com/releases/2015/07/150722115529.htm (accessed May 23, 2017).

RELATED STORIES