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Improved outcomes associated with stem cell transplantation for children with serious chronic leukemia

Date:
July 23, 2015
Source:
Childrens Hospital Los Angeles
Summary:
Researchers have shown greatly improved outcomes in using stem cell transplantation to treat patients with a serious but very rare form of chronic blood cancer called juvenile myelomonocytic leukemia (JMML).
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Researchers in the Division of Hematology, Oncology and Blood & Marrow Transplantation at Children's Hospital Los Angeles have shown greatly improved outcomes in using stem cell transplantation to treat patients with a serious but very rare form of chronic blood cancer called juvenile myelomonocytic leukemia (JMML).

Allogeneic hematopoietic stem cell transplantation (HSCT) involves the transplantation of stem cells from a donor, which may be derived from bone marrow, peripheral blood or umbilical cord blood. The recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. It is the only reported cure for JMML; however best outcomes of the therapy have shown only that half of patients can be cured from their disease. According to the researchers, there is currently no standard conditioning regimen for children with JMML undergoing HSCT.

The CHLA study, led by Hisham Abdel-Azim, MD, looked at children with JMML who underwent HSCT at Children's Hospital Los Angeles. All of the patients were alive and in clinical remission.

"The lack of transplant-related mortality in the group of children we studied at the Children's Center for Cancer and Blood Diseases at CHLA suggests that BUMEL (Intravenous Busulfan and Melphalan) may represent a successful HSCT high-dose chemotherapy regimen," said Abdel-Azim. "It is also possible that administering conventional dose chemotherapy, before HSCT, to patients with more progressive disease may have contributed to the improved outcomes."

He added that a follow up clinical trial is warranted to confirm these promising findings, which are published in the July 23, 2015, issue of the journal Blood.


Story Source:

Materials provided by Childrens Hospital Los Angeles. Note: Content may be edited for style and length.


Journal Reference:

  1. Q. Zhao, K. M. Mahadeo, N. Kapoor, H. Abdel-Azim. Improved outcomes associated with hematopoietic stem cell transplantation for patients with juvenile myelomonocytic leukemia. Blood, 2015; 126 (4): 561 DOI: 10.1182/blood-2015-05-644161

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Childrens Hospital Los Angeles. "Improved outcomes associated with stem cell transplantation for children with serious chronic leukemia." ScienceDaily. ScienceDaily, 23 July 2015. <www.sciencedaily.com/releases/2015/07/150723125611.htm>.
Childrens Hospital Los Angeles. (2015, July 23). Improved outcomes associated with stem cell transplantation for children with serious chronic leukemia. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/07/150723125611.htm
Childrens Hospital Los Angeles. "Improved outcomes associated with stem cell transplantation for children with serious chronic leukemia." ScienceDaily. www.sciencedaily.com/releases/2015/07/150723125611.htm (accessed May 23, 2017).

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