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Case study reveals therapy to reduce sarcoidosis symptoms in 5q-myelodysplastic syndrome

Use of lenalidomide in 5q-myelodysplastic syndrome provides new hope in sarcoidosis therapy

Date:
August 4, 2015
Source:
American College of Chest Physicians
Summary:
A case study found lenalidomide treatments may have an immediate effect in the treatment of sarcoidosis-related symptoms. Sarcoidosis, a disease that involves abnormal collections of inflammatory cells that can form nodules in various organs, can affect individuals from all racial and age groups. To date, no optimal therapies have been effective in managing this condition.
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A case study published in the August issue of the journal CHEST found lenalidomide treatments may have an immediate effect in the treatment of sarcoidosis-related symptoms. Sarcoidosis, a disease that involves abnormal collections of inflammatory cells that can form nodules in various organs, can affect individuals from all racial and age groups. To date, no optimal therapies have been effective in managing this condition.

This finding was reported in the case of a 71-year-old woman with a long-standing history of refractory pulmonary sarcoidosis. Upon receiving two cycles of treatment with lenalidomide, the patient's breathlessness, fatigue, daily activity, and quality of life showed significant improvement, and her lung function testing demonstrated a remarkable increase in vital capacity. The case is the first of its kind to report the potential effects of lenalidomide as a therapeutic option in patients with pulmonary sarcoidosis.

The entire study "Use of Lenalidomide in 5q-Myelodysplastic Syndrome Provides Novel Treatment Prospects in Management of Pulmonary Sarcoidosis" can be viewed in the August issue of CHEST.


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Materials provided by American College of Chest Physicians. Note: Content may be edited for style and length.


Journal Reference:

  1. Mahsa Jafari Giv, Alam Yoosuff, Ali Bazargan. Use of Lenalidomide in 5q-Myelodysplastic Syndrome Provides Novel Treatment Prospects in Management of Pulmonary Sarcoidosis. CHEST Journal, 2015; 148 (2): e35 DOI: 10.1378/chest.14-2529

Cite This Page:

American College of Chest Physicians. "Case study reveals therapy to reduce sarcoidosis symptoms in 5q-myelodysplastic syndrome: Use of lenalidomide in 5q-myelodysplastic syndrome provides new hope in sarcoidosis therapy." ScienceDaily. ScienceDaily, 4 August 2015. <www.sciencedaily.com/releases/2015/08/150804160926.htm>.
American College of Chest Physicians. (2015, August 4). Case study reveals therapy to reduce sarcoidosis symptoms in 5q-myelodysplastic syndrome: Use of lenalidomide in 5q-myelodysplastic syndrome provides new hope in sarcoidosis therapy. ScienceDaily. Retrieved May 8, 2017 from www.sciencedaily.com/releases/2015/08/150804160926.htm
American College of Chest Physicians. "Case study reveals therapy to reduce sarcoidosis symptoms in 5q-myelodysplastic syndrome: Use of lenalidomide in 5q-myelodysplastic syndrome provides new hope in sarcoidosis therapy." ScienceDaily. www.sciencedaily.com/releases/2015/08/150804160926.htm (accessed May 8, 2017).