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High-fat diet may cause changes in brain that lead to anxiety, depression

Date:
October 19, 2015
Source:
Wiley
Summary:
A new study in mice reveals that increased body weight and high blood sugar as a result of consuming a high-fat diet may cause anxiety and depressive symptoms and measurable changes in the brain.
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A new study in mice reveals that increased body weight and high blood sugar as a result of consuming a high-fat diet may cause anxiety and depressive symptoms and measurable changes in the brain.

Also, the beneficial effects of an antidepressant were blunted in mice fed a high-fat diet. "When treating depression, in general there is no predictor of treatment resistance," said Dr. Bruno Guiard, senior author of the British Journal of Pharmacology study. "So if we consider metabolic disorders as a putative treatment resistance predictor, this should encourage psychiatrists to put in place a personalized treatment with antidepressant drugs that do not further destabilize metabolism."

On the other hand, taking mice off a high-fat diet completely reversed the animals' metabolic impairments and lessened their anxious symptoms. "This finding reinforcing the idea that the normalization of metabolic parameters may give a better chance of achieving remission, particularly in depressed patients with type 2 diabetes," said Dr. Guiard.

The results set the tone for future investigations on potential mechanisms that may link metabolic and psychiatric disorders.


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Materials provided by Wiley. Note: Content may be edited for style and length.


Journal Reference:

  1. Juliane Zemdegs, Gaël Quesseveur, David Jarriault, Luc Pénicaud, Xavier Fioramonti, Bruno P. Guiard. High fat diet-induced metabolic disorders impairs serotonergic function and anxiety-like behaviours in mice. British Journal of Pharmacology, 2015; DOI: 10.1111/bph.13343

Cite This Page:

Wiley. "High-fat diet may cause changes in brain that lead to anxiety, depression." ScienceDaily. ScienceDaily, 19 October 2015. <www.sciencedaily.com/releases/2015/10/151019123204.htm>.
Wiley. (2015, October 19). High-fat diet may cause changes in brain that lead to anxiety, depression. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2015/10/151019123204.htm
Wiley. "High-fat diet may cause changes in brain that lead to anxiety, depression." ScienceDaily. www.sciencedaily.com/releases/2015/10/151019123204.htm (accessed May 24, 2017).

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