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Children born to women after bariatric surgery at higher risk of obesity, diabetes

Date:
November 19, 2015
Source:
American Physiological Society (APS)
Summary:
Weight-loss surgery can boost fertility in women and reduce the risk of pregnancy complications that commonly occur in obese women. However, a new study in rats suggests that weight-loss surgery alters mothers’ hormone and chemical balance, which harms offspring during gestation and later in life.
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Studies show that weight-loss surgery can boost fertility in women and reduce the risk of pregnancy complications that commonly occur in obese women, such as gestational diabetes and preeclampsia. While weight loss surgery improves the metabolic health of mothers, new findings to be presented at Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender support that such surgery has negative consequences on children born after the procedure.

Researchers at the University of Mississippi Medical Center previously observed in rats that offspring born to mothers who underwent vertical sleeve gastrectomy (VSG), a weight loss surgery in which 80 percent of the stomach is removed, bore pups that were smaller than normal and more susceptible to developing diabetes and becoming obese. In this new study, the team observed that female rats who received VSG had smaller litters with smaller pups. Moreover, the placentas of these female rats showed greater activation of genes involved in inflammation and oxygen deficiency.

The data indicate that hormonal and chemical alterations induced by the surgery "may be driving reduced fetal growth. These data further support that the beneficial effects of VSG surgery in adult females may have negative consequences on gestation and beyond to their offspring," the research team said.


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Materials provided by American Physiological Society (APS). Note: Content may be edited for style and length.


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American Physiological Society (APS). "Children born to women after bariatric surgery at higher risk of obesity, diabetes." ScienceDaily. ScienceDaily, 19 November 2015. <www.sciencedaily.com/releases/2015/11/151119162607.htm>.
American Physiological Society (APS). (2015, November 19). Children born to women after bariatric surgery at higher risk of obesity, diabetes. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2015/11/151119162607.htm
American Physiological Society (APS). "Children born to women after bariatric surgery at higher risk of obesity, diabetes." ScienceDaily. www.sciencedaily.com/releases/2015/11/151119162607.htm (accessed May 24, 2017).

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