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Increased diabetes risk associated with youth antipsychotic treatment, rare with small absolute incidence rates

Date:
January 20, 2016
Source:
The JAMA Network Journals
Summary:
Antipsychotic treatment in youth was associated with an increased risk of type 2 diabetes, although the condition appeared to be rare with small absolute incidence rates, a review of medical literature suggests.
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A review of medical literature suggests antipsychotic treatment in youth was associated with an increased risk of type 2 diabetes, although the condition appeared to be rare with small absolute incidence rates, according to an article published online by JAMA Psychiatry.

The meta-analysis led by Christoph U. Correll, M.D., of the Hofstra Northwell School of Medicine, Hempstead, N.Y., included 13 studies with 185,105 youth exposed to antipsychotics (average age 14.1 years and 59.5 percent male).

The cumulative risk of type 2 diabetes and its incidence rate per patient year of antipsychotic exposure were 2.6 times and three times higher compared with healthy controls and 2.1 times and 1.8 times higher compared with psychiatric patients not exposed to antipsychotics.

The study notes the smaller difference compared with psychiatrically ill patients than to healthy controls reflects that unhealthy lifestyle behaviors and other pharmacological treatments associated with psychiatric disorders likely also contribute to the risk of weight gain or obesity, metabolic abnormalities and type 2 diabetes.


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Materials provided by The JAMA Network Journals. Note: Content may be edited for style and length.


Journal Reference:

  1. Britta Galling, Alexandra Roldán, René E. Nielsen, Jimmi Nielsen, Tobias Gerhard, Maren Carbon, Brendon Stubbs, Davy Vancampfort, Marc De Hert, Mark Olfson, Kai G. Kahl, Andres Martin, Jeff J. Guo, Hsien-Yuan Lane, Fung-Chang Sung, Chun-Hui Liao, Celso Arango, Christoph U. Correll. Type 2 Diabetes Mellitus in Youth Exposed to Antipsychotics. JAMA Psychiatry, 2016; DOI: 10.1001/jamapsychiatry.2015.2923

Cite This Page:

The JAMA Network Journals. "Increased diabetes risk associated with youth antipsychotic treatment, rare with small absolute incidence rates." ScienceDaily. ScienceDaily, 20 January 2016. <www.sciencedaily.com/releases/2016/01/160120115602.htm>.
The JAMA Network Journals. (2016, January 20). Increased diabetes risk associated with youth antipsychotic treatment, rare with small absolute incidence rates. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/01/160120115602.htm
The JAMA Network Journals. "Increased diabetes risk associated with youth antipsychotic treatment, rare with small absolute incidence rates." ScienceDaily. www.sciencedaily.com/releases/2016/01/160120115602.htm (accessed May 23, 2017).

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