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Study examines associations of HPV types, risk of head and neck cancer

Date:
January 21, 2016
Source:
The JAMA Network Journals
Summary:
A new study suggests detection of human papillomavirus (HPV)-16 in the oral cavity was associated with 22-times increased risk of oropharyngeal squamous cell carcinoma.
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A new study suggests detection of human papillomavirus (HPV)-16 in the oral cavity was associated with 22-times increased risk of oropharyngeal squamous cell carcinoma.

The study by Ilir Agalliu, M.D., Sc.D., of the Albert Einstein College of Medicine, New York, and coauthors also reports positive associations of other oral HPVs usually detected on the skin with the risk of head and neck squamous cell carcinoma (HNSCC), which suggests the role of HPV in HNSCC may be more important than currently recognized. The study was carried out among 96,650 participants from two large study groups who were cancer-free at baseline and had available mouthwash samples. There were 132 cases of HNSCC identified during an average follow-up of almost four years. The study included 396 healthy individuals (three for every case of HNSCC). The authors note limitations of the study because of its small sample size, which reflects the rarity of HNSCC.

"The use of easily collected oral mouthwash samples can provide a prospective marker for risk of HNSCC and oropharyngeal SCC," the study concludes.


Story Source:

The above post is reprinted from materials provided by The JAMA Network Journals. Note: Content may be edited for style and length.


Journal Reference:

  1. Dana E. Rollison, PhD; Maura L. Gillison, MD, PhD. The Alpha, Beta, Gammas of Oral Human Papillomavirus Infection and Head and Neck Cancer Risk. JAMA Oncology, January 2016 DOI: 10.1001/jamaoncol.2015.5504

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The JAMA Network Journals. "Study examines associations of HPV types, risk of head and neck cancer." ScienceDaily. ScienceDaily, 21 January 2016. <www.sciencedaily.com/releases/2016/01/160121130341.htm>.
The JAMA Network Journals. (2016, January 21). Study examines associations of HPV types, risk of head and neck cancer. ScienceDaily. Retrieved August 27, 2016 from www.sciencedaily.com/releases/2016/01/160121130341.htm
The JAMA Network Journals. "Study examines associations of HPV types, risk of head and neck cancer." ScienceDaily. www.sciencedaily.com/releases/2016/01/160121130341.htm (accessed August 27, 2016).