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Short-lived killifish reveals link between gene expression, longevity

Date:
February 24, 2016
Source:
Cell Press
Summary:
It's well known that genetic differences among individuals influence lifespan, but a new study suggests that differences in patterns of gene expression in youth may also predict longevity. Researchers of the shortest-lived vertebrate -- the African turquoise killifish -- found that when genes involved in a cell's energy production are less active at a young age, the animals tend to live longer.
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It's well known that genetic differences among individuals influence lifespan, but a new study appearing February 24 in Cell Systems suggests that differences in patterns of gene expression in youth may also predict longevity. Researchers of the shortest-lived vertebrate--the African turquoise killifish--found that when genes involved in a cell's energy production are less active at a young age, the animals tend to live longer.

Alessandro Cellerino of the Scuola Normale Superiore in Pisa, Italy, and the Leibniz Institute on Aging in Jena, Germany, and his colleagues analyzed the expression of genes in small biopsies from the fins of killifish at different times during the animals' lives, and they divided the fish into groups based on their longevity. Even under optimal conditions, the fish do not live beyond 4 to 12 months.

The team discovered that genes that are responsible for cellular respiration--the process by which mitochondria within cells use oxygen to burn sugar and produce energy--were less active at a young age in the fish that were long-lived.

When the researchers exposed the fish to a very low dose of a natural poison called rotenone, which inhibits the proteins (that collectively form mitochondrial complex I) responsible for the first step of cellular respiration, the fish lived longer.

While more information is needed to determine if the findings apply to humans, Cellerino notes that the function of mitochondria decreases with age in both humans and killifish alike. "Up to the present, it was thought that improving mitochondrial function would improve health in aged people; however, our results indicate a more complex scenario where the partial inhibition of mitochondrial function paradoxically has beneficial effects," he says.

This may occur because such inhibition produces a small amount of free radicals that do not harm the cells but can stimulate a positive, adaptive response. "This mechanism of adaptation after stress is called hormesis, and it was recently demonstrated that the positive effects of physical exercise in humans are due to hormesis and are destroyed by treatment with antioxidants," Cellerino explains.

This latest research suggests that the effects of aging on mitochondria may involve a compensatory response rather than one that causes problems. "This obviously has implications on the development of strategies to improve health in older people and prevent aging-associated diseases," Cellerino says.

Interestingly, there are FDA-approved drugs that inhibit mitochondrial complex I. Metformin, one such drug that is prescribed to treat type 2 diabetes, has been shown to extend the lifespan of mice. "Based on our data, we strongly suspect that the effect of metformin was due to inhibition of complex I and not to its anti-diabetic action," he says.


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Journal Reference:

  1. Baumgart and Priebe et al. Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan. Cell Systems, February 2016 DOI: 10.1016/j.cels.2016.01.014

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Cell Press. "Short-lived killifish reveals link between gene expression, longevity." ScienceDaily. ScienceDaily, 24 February 2016. <www.sciencedaily.com/releases/2016/02/160224145546.htm>.
Cell Press. (2016, February 24). Short-lived killifish reveals link between gene expression, longevity. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/02/160224145546.htm
Cell Press. "Short-lived killifish reveals link between gene expression, longevity." ScienceDaily. www.sciencedaily.com/releases/2016/02/160224145546.htm (accessed May 23, 2017).

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