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Drug discovery paradigm targets Tau protein aggregation linked to the Alzheimer's disease

New research demonstrates novel drug discovery paradigm to target the aggregation of the Tau protein linked to the onset of Alzheimer's and other related neurodegenerative diseases

Date:
February 26, 2016
Source:
Bentham Science Publishers
Summary:
New research demonstrates novel drug discovery paradigm to target the aggregation of the Tau protein linked to the onset of Alzheimer's and other related neurodegenerative diseases.
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Dementia and other tauopathies, most notably Alzheimer's disease, embody a class of neurodegenerative diseases associated with the aggregation of the Tau protein in the human brain. These diseases represent one of the leading causes of death and disability in the elderly population in the western world, with no current effective therapy.

An international team of scientists led by Dr. Gergely Tóth at University of Cambridge (UK) and at Hungarian Academy of Sciences (Hungary), with Professor Eckhard Mandelkow at Deutsches Zentrum fu?r Neurodegenerative Erkrankungen (Germany) in collaboration with Novalix (France) and Elan Pharmaceuticals (USA) reported the development of a novel therapeutic approach to target the monomeric Tau protein by small molecule drug candidates to maintain the protein's native function and reduce its misfolding and aggregation, which is linked to the onset of these diseases. The study was recently published in Current Alzheimers Research (CAR) and was selected as Editor's Choice by Prof. D. K. Lahiri's, (Editor-in-Chief,)

The Tau protein is an intrinsically disordered protein (IDP), a class of proteins that lack stable 3D structure. Because of this, targeting it using small molecules has been challenging. To tackle this challenge, the scientific team applied a unique binding screening methodology, applied by Novalix, to detect the binding between small molecules and Tau. This led to the identification of a diverse set of novel fragment and lead-like small molecules capable of binding Tau, a part of which reduced the aggregation of Tau in vitro and in a cellular model of Tauopathies.

The study demonstrated for the first time that monomeric Tau can be a viable receptor of small drug-like molecules, and supports the potential and practical feasibility of the therapeutic strategy to target early phases of the aggregation pathway of Tau and potentially other IDPs by small molecules, thereby eliminating the formation of potential toxic misfolded protein species. The researchers suggest that the presented drug discovery paradigm has general applicability, "the drug discovery approach that we present can be applied to other IDPs linked to other misfolding diseases such as Alzheimer's and Parkinson's diseases."


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Materials provided by Bentham Science Publishers. Note: Content may be edited for style and length.


Journal Reference:

  1. Marcus Pickhardt, Thomas Neumann, Daniel Schwizer, Kari Callaway, Michele Vendruscolo, Dale Schenk, Peter George-Hyslop, Eva Mandelkow, Christopher Dobson, Lisa McConlogue, Eckhard Mandelkow, Gergely Toth. Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies. Current Alzheimer Research, 2015; 12 (9): 814 DOI: 10.2174/156720501209151019104951

Cite This Page:

Bentham Science Publishers. "Drug discovery paradigm targets Tau protein aggregation linked to the Alzheimer's disease: New research demonstrates novel drug discovery paradigm to target the aggregation of the Tau protein linked to the onset of Alzheimer's and other related neurodegenerative diseases." ScienceDaily. ScienceDaily, 26 February 2016. <www.sciencedaily.com/releases/2016/02/160226115215.htm>.
Bentham Science Publishers. (2016, February 26). Drug discovery paradigm targets Tau protein aggregation linked to the Alzheimer's disease: New research demonstrates novel drug discovery paradigm to target the aggregation of the Tau protein linked to the onset of Alzheimer's and other related neurodegenerative diseases. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2016/02/160226115215.htm
Bentham Science Publishers. "Drug discovery paradigm targets Tau protein aggregation linked to the Alzheimer's disease: New research demonstrates novel drug discovery paradigm to target the aggregation of the Tau protein linked to the onset of Alzheimer's and other related neurodegenerative diseases." ScienceDaily. www.sciencedaily.com/releases/2016/02/160226115215.htm (accessed May 26, 2017).

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