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Hormone treatment in transgender persons could shed light on role of sex hormones in bone density

Date:
May 30, 2016
Source:
European Society of Endocrinology
Summary:
Male-to-female (MtF) transgender persons have a greater increase in bone mineral density than female-to-male (FtM) persons in their first year of hormone treatment. The research helps scientists further understand the roles sex hormones play on bone development and maintenance in both sexes.
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Male-to-female (MtF) transgender persons have a greater increase in bone mineral density than female-to-male (FtM) persons in their first year of hormone treatment. The research, presented at the European Congress of Endocrinology in Munich, helps scientists further understand the roles sex hormones play on bone development and maintenance in both sexes.

As the number of people seeking gender reassignment treatment continues to increase globally, there is an ever-greater need for scientists and clinicians to understand the effects of cross-gender hormonal treatment on the human body. Within the first year of gender transition, applicants are treated with sex hormones: MtF persons receive oestrogen, whilst FtM persons receive testosterone.

It is known that oestrogen increases bone density, however, whilst it is known that testosterone increases bone size, its effects on bone density are still unknown. To further investigate, a research team from VU University Medical Centre in Amsterdam completed an observational study of 188 adults undergoing hormone treatment for gender reassignment. Bone mineral density was measured both before and after one year of hormone treatment; the results showed that MtF persons receiving oestrogen had an average increase in spine bone density of 3.72%, compared to only a 1% increase in FtM persons receiving testosterone.

These results confirm our understanding that oestrogen increases bone density, and suggest that testosterone does not, or does so to a lesser extent. Interestingly, in FtM transgender persons who were post-menopausal with low pre-treatment oestrogen levels, bone density of the spine was seen to increase by 4.5% following testosterone treatment.

"As this increase was only found in those with low pre-treatment oestrogen levels, it might suggest that in biological adult women (pre-menopause) testosterone primarily affects bone density through its conversion into oestrogen," said Dr Chantal Wiepjes, lead author of the study.

"Our next steps will be to investigate what the long-term effects of hormone treatment are on bone density. Patients undergoing hormone therapy routinely have bone density scans, which might give them the impression that hormone treatment can have adverse effects on their bones. Therefore, a more solid molecular long-term understanding of the changes may reassure them," continued Dr Chantal Wiepjes. "I also think transitioning patients should be aware that the changes caused by these hormones aren't just external -- their internal structure changes too."

As well as improving understanding of treatments within the transgender community, by studying the effects of cross-sex hormone treatment, the team hopes to more clearly understand the role of oestrogen in biological males, and the role of testosterone in biological females.

Whilst it should be noted that the observational study did not compare results to a control group, the team feel that differences seen in post-menopausal FtM persons suggest that it is unlikely the changes in bone density seen were merely due to age or timing.


Story Source:

Materials provided by European Society of Endocrinology. Note: Content may be edited for style and length.


Journal Reference:

  1. Chantal Wiepjes, Mariska Vlot, Maartje Klaver, Jongh Renate de, Paul Lips, Annemieke Heijboer, Alessandra Fisher, Thomas Schreiner, Guy T'Sjoen, Heijer Martin den. An increase of bone mineral density in male-to-female and female-to-male transgender persons after one year cross-sex hormonal treatment. Endocrine Abstracts, 2016; DOI: 10.1530/endoabs.41.OC11.1

Cite This Page:

European Society of Endocrinology. "Hormone treatment in transgender persons could shed light on role of sex hormones in bone density." ScienceDaily. ScienceDaily, 30 May 2016. <www.sciencedaily.com/releases/2016/05/160530190141.htm>.
European Society of Endocrinology. (2016, May 30). Hormone treatment in transgender persons could shed light on role of sex hormones in bone density. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2016/05/160530190141.htm
European Society of Endocrinology. "Hormone treatment in transgender persons could shed light on role of sex hormones in bone density." ScienceDaily. www.sciencedaily.com/releases/2016/05/160530190141.htm (accessed May 26, 2017).

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