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Prognostic factor indicates risk of cancer recurrence following radical prostatectomy

Date:
June 27, 2016
Source:
Medical University of Vienna
Summary:
Slightly more than 10% of all patients who undergo successful surgery for prostate cancer have an elevated risk of tumor recurrence afterwards – especially as metastases. Under the microscope, it is possible to identify invasion of the tumor into the lymph and blood vessels, this being the tumor behavior responsible for the formation of metastases, so that it can be used as a prognostic factor, report researchers.
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Slightly more than 10% of all patients who undergo successful surgery for prostate cancer have an elevated risk of tumor recurrence afterwards -- especially as metastases. Under the microscope, it is possible to identify invasion of the tumor into the lymph and blood vessels, this being the tumor behaviour responsible for the formation of metastases, so that it can be used as a prognostic factor. This has now been demonstrated by Harun Fajkovic of MedUni Vienna's Department of Urology in a study involving 7,000 patients in "Urologic Oncology." Fajkovic will also report on the latest research findings at the largest international congress on prostate cancer "PROSCA," currently taking place in Vienna.

Lymphovascular invasion (LVI) means that malignant cancer cells "invade" the blood vessels and lymphatic system, from whence they can be transported onwards. "They can implant themselves, for example as micro-metastases in the lung or spine and then slowly replicate to form a new tumor at another site in the body," explains Fajkovic.

Detection of LVI, in combination with other characteristics in the pathological analysis of the resected tumor, therefore acts as a sort of alert, even if the patient's post-operative PSA value, the current marker for prostate cancer, is below the critical limit. Fajkovic: "Patients could then conceivably be offered additional supportive treatment straightaway, for example, radiotherapy or chemotherapy -- rather than waiting to see." LVI has also been identified as an independent prognostic factor in other types of cancer, such as breast cancer or bladder cancer.

According to Statistik Austria (status 2013), around 5,000 men in Austria develop prostate cancer (adenocarcinoma) every year. Approximately 1,150 of those affected die over the same period. Prostate cancer is the third commonest male cancer worldwide.


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Materials provided by Medical University of Vienna. Note: Content may be edited for style and length.


Journal Reference:

  1. Harun Fajkovic, Romain Mathieu, Ilaria Lucca, Manuela Hiess, Nicolai Hübner, Bashir Al Hussein Al Awamlh, Richard Lee, Alberto Briganti, Pierre Karakiewicz, Yair Lotan, Morgan Roupret, Michael Rink, Luis Kluth, Wolfgang Loidl, Christian Seitz, Tobias Klatte, Gero Kramer, Martin Susani, Shahrokh F. Shariat. Validation of lymphovascular invasion is an independent prognostic factor for biochemical recurrence after radical prostatectomy. Urologic Oncology: Seminars and Original Investigations, 2016; 34 (5): 233.e1 DOI: 10.1016/j.urolonc.2015.10.013

Cite This Page:

Medical University of Vienna. "Prognostic factor indicates risk of cancer recurrence following radical prostatectomy." ScienceDaily. ScienceDaily, 27 June 2016. <www.sciencedaily.com/releases/2016/06/160627095320.htm>.
Medical University of Vienna. (2016, June 27). Prognostic factor indicates risk of cancer recurrence following radical prostatectomy. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2016/06/160627095320.htm
Medical University of Vienna. "Prognostic factor indicates risk of cancer recurrence following radical prostatectomy." ScienceDaily. www.sciencedaily.com/releases/2016/06/160627095320.htm (accessed May 26, 2017).

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