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Losing weight lowered levels of proteins associated with tumor growth

Obese women who lost weight significantly lowered levels of proteins in the blood that help certain tumors grow

Date:
July 14, 2016
Source:
Fred Hutchinson Cancer Research Center
Summary:
Overweight or obese women who lost weight through diet or a combination of diet and exercise also significantly lowered levels of proteins in the blood that help certain tumors grow, according to a study.
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Overweight or obese women who lost weight through diet or a combination of diet and exercise also significantly lowered levels of proteins in the blood that help certain tumors grow, according to a Fred Hutchinson Cancer Research Center study published July 14 in Cancer Research, a journal of the American Association for Cancer Research.

Two study leaders -- Dr. Catherine Duggan, principal staff scientist in the Public Health Sciences Division, and Dr. Anne McTiernan, cancer prevention researcher in the Public Health Sciences Division and the article's senior author -- are available to provide details on the study and its implications.

The study:

  • Measured three proteins that are known to enhance tumor-related angiogenesis -- the formation of blood vessels that feed tumors and enable them to grow.
  • Was intended to see how cancer-promoting proteins changed when overweight, sedentary, postmenopausal women lost weight through diet or diet and exercise over the course of a year.
  • Enrolled 439 healthy women (they did not have cancer), placing each participant in one of four study arms:
    • Calorie- and fat-restricted diet.
    • Aerobic exercise five days a week.
    • Combined diet and exercise.
    • Control (no intervention).
  • Found that women in the diet arm and the diet and exercise arm lost more weight and had significantly lower levels of angiogenesis-related proteins, compared with women in the exercise-only arm and the control arm.

The authors said that it is known that being overweight and having a sedentary lifestyle are associated with increased risk for developing certain cancers, but the reasons for this relationship are not clear.

This study shows that weight loss may be a safe and effective way to improve the "angiogenic profile" of healthy individuals, meaning they would have lower blood levels of cancer-promoting proteins. Although the researchers cannot say for certain that this would impact the growth of tumors, they believe there could be an association between reduced protein levels and a less favorable environment for tumor growth.


Story Source:

Materials provided by Fred Hutchinson Cancer Research Center. Original written by Bill Briggs. Note: Content may be edited for style and length.


Journal Reference:

  1. Catherine Duggan, Jean de Dieu Tapsoba, Ching-Yun Wang, Anne McTiernan. Dietary Weight Loss and Exercise Effects on Serum Biomarkers of Angiogenesis in Overweight Postmenopausal Women: A Randomized Controlled Trial. Cancer Research, July 2016 DOI: 10.1158/0008-5472.CAN-16-0399

Cite This Page:

Fred Hutchinson Cancer Research Center. "Losing weight lowered levels of proteins associated with tumor growth: Obese women who lost weight significantly lowered levels of proteins in the blood that help certain tumors grow." ScienceDaily. ScienceDaily, 14 July 2016. <www.sciencedaily.com/releases/2016/07/160714091343.htm>.
Fred Hutchinson Cancer Research Center. (2016, July 14). Losing weight lowered levels of proteins associated with tumor growth: Obese women who lost weight significantly lowered levels of proteins in the blood that help certain tumors grow. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2016/07/160714091343.htm
Fred Hutchinson Cancer Research Center. "Losing weight lowered levels of proteins associated with tumor growth: Obese women who lost weight significantly lowered levels of proteins in the blood that help certain tumors grow." ScienceDaily. www.sciencedaily.com/releases/2016/07/160714091343.htm (accessed May 24, 2017).

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