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Acetaminophen not associated with worse asthma in kids

Date:
September 7, 2016
Source:
Ann & Robert H. Lurie Children's Hospital of Chicago
Summary:
Children with mild, persistent asthma did not have worse asthma symptoms after taking acetaminophen (e.g., Tylenol) for pain or fever, compared to using ibuprofen (e.g., Advil), according to the results of a randomized, double-blind clinical trial.
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Children with mild, persistent asthma did not have worse asthma symptoms after taking acetaminophen (e.g., Tylenol) for pain or fever, compared to using ibuprofen (e.g., Advil), according to the results of a randomized, double-blind clinical trial recently published in the New England Journal of Medicine.

Previous observational reports have linked the use of acetaminophen with asthma exacerbations, however well-designed clinical trials evaluating the association were lacking. Some physicians have recommended that children with asthma completely avoid taking acetaminophen until data on safety become available. "Our study is the first to provide rigorous evidence that acetaminophen is as safe as ibuprofen for children with asthma," said Rachel Robison, MD, study co-author and allergist at Ann & Robert H. Lurie Children's Hospital of Chicago, as well as Assistant Professor of Allergy/Immunology at Northwestern University Feinberg School of Medicine. "This should be reassuring for parents and physicians."

The 48-week study, funded by the National Heart, Lung, and Blood Institute, was conducted at 18 sites in the United States. It included 300 children, 1 to 5 years old, who had asthma symptoms on more than two days per week, but not daily, and required treatment every day to manage their disease. During the study, caregivers gave children either acetaminophen or ibuprofen as needed. None of the study investigators, caregivers, or children knew which study drug each child was receiving.

"We measured asthma exacerbation rate, the number of days of asthma control, the need for rescue medications and unscheduled medical visits for asthma," said Jacqueline Pongracic, MD, study co-author, Head of Allergy and Immunology Division at Lurie Children's and Professor of Pediatrics and Medicine at Northwestern University Feinberg School of Medicine. "We did not find a higher risk of asthma worsening in children taking acetaminophen compared to ibuprofen, even during periods of respiratory illness."

More research is needed in older children with asthma and those with more severe disease.


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Materials provided by Ann & Robert H. Lurie Children's Hospital of Chicago. Note: Content may be edited for style and length.


Journal Reference:

  1. William J. Sheehan, David T. Mauger, Ian M. Paul, James N. Moy, Susan J. Boehmer, Stanley J. Szefler, Anne M. Fitzpatrick, Daniel J. Jackson, Leonard B. Bacharier, Michael D. Cabana, Ronina Covar, Fernando Holguin, Robert F. Lemanske, Fernando D. Martinez, Jacqueline A. Pongracic, Avraham Beigelman, Sachin N. Baxi, Mindy Benson, Kathryn Blake, James F. Chmiel, Cori L. Daines, Michael O. Daines, Jonathan M. Gaffin, Deborah A. Gentile, W. Adam Gower, Elliot Israel, Harsha V. Kumar, Jason E. Lang, Stephen C. Lazarus, John J. Lima, Ngoc Ly, Jyothi Marbin, Wayne J. Morgan, Ross E. Myers, J. Tod Olin, Stephen P. Peters, Hengameh H. Raissy, Rachel G. Robison, Kristie Ross, Christine A. Sorkness, Shannon M. Thyne, Michael E. Wechsler, Wanda Phipatanakul. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. New England Journal of Medicine, 2016; 375 (7): 619 DOI: 10.1056/NEJMoa1515990

Cite This Page:

Ann & Robert H. Lurie Children's Hospital of Chicago. "Acetaminophen not associated with worse asthma in kids." ScienceDaily. ScienceDaily, 7 September 2016. <www.sciencedaily.com/releases/2016/09/160907114008.htm>.
Ann & Robert H. Lurie Children's Hospital of Chicago. (2016, September 7). Acetaminophen not associated with worse asthma in kids. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2016/09/160907114008.htm
Ann & Robert H. Lurie Children's Hospital of Chicago. "Acetaminophen not associated with worse asthma in kids." ScienceDaily. www.sciencedaily.com/releases/2016/09/160907114008.htm (accessed May 24, 2017).

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