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How cancer's 'invisibility cloak' works

Date:
September 30, 2016
Source:
University of British Columbia
Summary:
Researchers have discovered how cancer cells become invisible to the body's immune system, a crucial step that allows tumors to metastasize and spread throughout the body.
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UBC researchers have discovered how cancer cells become invisible to the body's immune system, a crucial step that allows tumors to metastasize and spread throughout the body.

"The immune system is efficient at identifying and halting the emergence and spread of primary tumors but when metastatic tumors appear, the immune system is no longer able to recognize the cancer cells and stop them," said Wilfred Jefferies, senior author of the study working in the Michael Smith Laboratories and a professor of Medical Genetics and Microbiology and Immunology at UBC.

"We discovered a new mechanism that explains how metastatic tumors can outsmart the immune system and we have begun to reverse this process so tumors are revealed to the immune system once again."

Cancer cells genetically change and evolve over time. Researchers discovered that as they evolve, they may lose the ability to create a protein known as interleukein-33, or IL-33. When IL-33 disappears in the tumor, the body's immune system has no way of recognizing the cancer cells and they can begin to spread, or metastasize.

The researchers found that the loss of IL-33 occurs in epithelial carcinomas, meaning cancers that begin in tissues that line the surfaces of organs. These cancers include prostate, kidney breast, lung, uterine, cervical, pancreatic, skin and many others.

Working in collaboration with researchers at the Vancouver Prostate Centre, and studying several hundred patients, they found that patients with prostate or renal (kidney) cancers whose tumors have lost IL-33, had more rapid recurrence of their cancer over a five-year period. They will now begin studying whether testing for IL-33 is an effective way to monitor the progression of certain cancers.

"IL-33 could be among the first immune biomarkers for prostate cancer and, in the near future, we are planning to examine this in a larger sample size of patients," said Iryna Saranchova, a PhD student in the department of microbiology and immunology and first author on the study.

Researchers have long tried to use the body's own immune system to fight cancer but only in the last few years have they identified treatments that show potential.

In this study Saranchova, Jefferies and their colleagues at the Michael Smith Laboratories, found that putting IL-33 back into metastatic cancers helped revive the immune system's ability to recognize tumors. Further research will examine whether this could be an effective cancer treatment in humans.

This study was published in the journal Scientific Reports.


Story Source:

Materials provided by University of British Columbia. Note: Content may be edited for style and length.


Journal Reference:

  1. Iryna Saranchova, Jeffrey Han, Hui Huang, Franz Fenninger, Kyung Bok Choi, Lonna Munro, Cheryl Pfeifer, Ian Welch, Alexander W. Wyatt, Ladan Fazli, Martin E. Gleave, Wilfred A. Jefferies. Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33. Scientific Reports, 2016; 6: 30555 DOI: 10.1038/srep30555

Cite This Page:

University of British Columbia. "How cancer's 'invisibility cloak' works." ScienceDaily. ScienceDaily, 30 September 2016. <www.sciencedaily.com/releases/2016/09/160930150333.htm>.
University of British Columbia. (2016, September 30). How cancer's 'invisibility cloak' works. ScienceDaily. Retrieved May 28, 2017 from www.sciencedaily.com/releases/2016/09/160930150333.htm
University of British Columbia. "How cancer's 'invisibility cloak' works." ScienceDaily. www.sciencedaily.com/releases/2016/09/160930150333.htm (accessed May 28, 2017).

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