Science News
from research organizations

First breath shapes the lung's immune system

Date:
February 21, 2017
Source:
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Summary:
With the first breath, the lungs require to develop immunological defense mechanisms while maintaining the gas exchange. The postnatal immunological development of the lungs remained largely unknown until a group of scientists shed light at a complex immune program that starts right after birth: the study reveals how first breath-induced interleukin-33 signaling shapes the performance of pulmonary immune cells and influences anti-bacterial defenses.
Share:
FULL STORY

The lung is an important interface between the body and the outside environment: with each breath, a surface of roughly 100 square meters exchanges oxygen for carbon dioxide. More than 10,000 liters of air pass adult lungs every day and with this come numerous viruses, bacteria and pollutants, which need to be prevented from entering the body.

To defend the organism from these intruders, the lungs harbor their own arsenal of highly specialized immune cells that are equipped to maintain the balance between host defense and tissue quiescence. However, how this balanced immune homeostasis in lungs emerged after birth, was largely unexplored. Now, for the first time, the group of Sylvia Knapp, Director of Medical Affairs at CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and Professor of Infection Biology at the Medical University of Vienna showed with the help of mouse models that the very first breath of a newborn releases crucial signals that shape the lifelong immunological milieu of lungs.

The study, published in Cell Reports, reveals that the mechanical forces of spontaneous ventilation at birth lead to the release of interleukin (IL)-33, a cytokine with a wide-range of effects: So-called "type 2 innate lymphoid cells" (ILC2s) follow the IL-33 signal and migrate into the lung tissue, where they release IL-13, another cytokine. This second signal determines the faith of alveolar macrophages by inducing the anti-inflammatory M2 phenotype.

"ILC2-cells are crucial in defending the lungs against parasites or influenza viruses, but little was known about their role in lung homeostasis," first author Simona Saluzzo, PhD Student at CeMM and the Medical University of Vienna, explains. "Now we understand that right after birth, ILC2 are responsible for the differentiation of alveolar macrophages into specialized cells that keep the immune system in check and ensure that the lungs stay calm and healthy to ensure proper gas exchange."

These ILC2-induced effects protect the lungs from excessive inflammation to daily encountered environmental triggers -- but there is a catch, senior author Sylvia Knapp emphasizes: "We could show in our study that the described mechanisms are crucial in achieving lung quiescence after the first contact with the outside world. However, these processes at the same time increase the susceptibility to bacterial infections, such as caused by pneumococci. In other words: The mechanism that maintains the lung function of gas exchange at the same time explains why bacterial pneumonia is the primary cause of death by an infectious disease in Western countries."


Story Source:

Materials provided by CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Note: Content may be edited for style and length.


Journal Reference:

  1. Simona Saluzzo, Anna-Dorothea Gorki, Batika M. J. Rana, Rui Martins, Seth Scanlon, Philipp Starkl, Karin Lakovits, Anastasiya Hladik, Ana Korosec, Omar Sharif, Joanna M. Warszawska, Helen Jolin, Ildiko Mesteri, Andrew N. J. McKenzie und Sylvia Knapp. First-breath induced type-2 pathways shape the lung immune environment. Cell Reports, 2017 DOI: 10.1016/j.celrep.2017.01.071

Cite This Page:

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. "First breath shapes the lung's immune system." ScienceDaily. ScienceDaily, 21 February 2017. <www.sciencedaily.com/releases/2017/02/170221120848.htm>.
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. (2017, February 21). First breath shapes the lung's immune system. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2017/02/170221120848.htm
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. "First breath shapes the lung's immune system." ScienceDaily. www.sciencedaily.com/releases/2017/02/170221120848.htm (accessed May 23, 2017).

RELATED STORIES