New! Sign up for our free email newsletter.
Science News
from research organizations

New elements responsible for instability in chromosomes

Date:
June 30, 2017
Source:
University of Seville
Summary:
RNA joins with DNA by chance or because of a disease, the structure of the chromatin, the protein envelope of the chromosomes is altered, causing breaks in the DNA, report investigators. Gene mutations involved in the transcription and transport of RNA also cause damage in DNA, which they have shown is caused by changes in the chromatin. In these circumstances, the DNA cannot replicate itself naturally, generating replication stress, mutations and chromosome mutations.
Share:
FULL STORY

Genome instability is the main risk factor in the development of tumours in humans. Understanding how, where, when and why these mutations are produced in DNA is one of the great objectives of the global scientific community. Therefore, a group of experts from the University of Seville and the Andalusian Center for Molecular Biology and Regenerative Medicine (Cabimer) has published a study that indicates a new element involved in this process: chromatin.

In the scientific article "Histone mutations separate R loops from genome instability induction" published in Molecular Cell, the researchers state that RNA joins with DNA by chance or because of a disease, the structure of the chromatin, the protein envelope of the chromosomes is altered, causing breaks in the DNA. Gene mutations involved in the transcription and transport of RNA also cause damage in DNA, which they have shown is caused by changes in the chromatin. In these circumstances, the DNA cannot replicate itself naturally, generating replication stress, mutations and chromosome mutations.

"By means of basic research on model organisms, we are trying to understand human genome instability to identify elements, which, in the future, might be able to be explored as targets of new anti-tumour medicines," explains the researcher responsible for the project and director of Cabimer, Andrés Aguilera. Also, he adds that "in this project, we have taken a step forward in showing that chromatin also plays a key role on some DNA mutations, especially those controlled by RNA. If we can show that this anomaly doesn't occur in healthy cells, we will be able to think about exploring these structures as possible therapeutic targets."


Story Source:

Materials provided by University of Seville. Note: Content may be edited for style and length.


Journal Reference:

  1. Desiré García-Pichardo, Juan C. Cañas, María L. García-Rubio, Belén Gómez-González, Ana G. Rondón, Andrés Aguilera. Histone Mutants Separate R Loop Formation from Genome Instability Induction. Molecular Cell, 2017; 66 (5): 597 DOI: 10.1016/j.molcel.2017.05.014

Cite This Page:

University of Seville. "New elements responsible for instability in chromosomes." ScienceDaily. ScienceDaily, 30 June 2017. <www.sciencedaily.com/releases/2017/06/170630105026.htm>.
University of Seville. (2017, June 30). New elements responsible for instability in chromosomes. ScienceDaily. Retrieved June 18, 2024 from www.sciencedaily.com/releases/2017/06/170630105026.htm
University of Seville. "New elements responsible for instability in chromosomes." ScienceDaily. www.sciencedaily.com/releases/2017/06/170630105026.htm (accessed June 18, 2024).

Explore More

from ScienceDaily

RELATED STORIES