New! Sign up for our free email newsletter.
Science News
from research organizations

Multiple sclerosis: Patients may benefit from over-the-counter therapy

Results will be tested in large-scale clinical trial

Date:
June 30, 2017
Source:
Oregon Health & Science University
Summary:
Over-the-counter antioxidant lipoic acid holds promise for treating patients with secondary progressive multiple sclerosis, a pilot study suggests. Researchers are using the findings from the pilot trial to design the expanded multi-site clinical trial to begin later this year in Portland and other sites that have yet to be finalized.
Share:
FULL STORY

Treatment options currently are limited for people suffering from secondary progressive multiple sclerosis. However, an OHSU pilot study suggests over-the-counter antioxidant lipoic acid holds promise in improving patients' lives.

The research was published June 28 in the journal Neuroimmunology & Neuroinflammation.

The randomized double-blind study involved 51 participants who completed the two-year trial. Twenty-seven people were given a 1,200-milogram daily dose of lipoic acid, with the remaining 24 participants given a placebo. Researchers are using the findings from the pilot trial to design the expanded multi-site clinical trial to begin later this year in Portland and other sites that have yet to be finalized.

"These are high doses," said lead author Rebecca Spain, M.D., M.S.P.H., an assistant professor of neurology in the OHSU School of Medicine. "And while it seems safe, we won't know whether it actually improves the lives of people with MS until we can replicate the results in the pilot study through a much bigger clinical trial. Fortunately, we're going to be able to answer that question with the participation of kind volunteers."

MS is a chronic condition that affects an estimated 2.3 million people worldwide. In MS, the sheath covering nerve fibers in the brain and spinal cord becomes damaged, slowing or blocking electrical signals from the brain reaching the eyes, muscles and other parts of the body.

The major finding of the pilot study involved measuring the degree to which lipoic acid arrested the rate of whole brain atrophy, as measured through magnetic resonance imaging.

The study revealed a 68 percent improvement over the placebo in slowing the rate of whole brain atrophy in patients with secondary progressive MS. For the sake of comparison, a clinical trial involving the recent FDA-approved pharmaceutical Ocrevus showed an 18 percent improvement over a placebo in slowing the rate of whole brain atrophy for patients with primary progressive forms of the disease.

In addition, the pilot study suggested improved walking times and fewer falls among study participants who took a daily dose of lipoic acid compared with those who received the placebo. Researchers are eager to test those outcomes in the larger clinical trial.

A companion study, published concurrently by Neuroimmunology & Neuroinflammation, measured the rate of absorption and clearance of lipoic acid through periodic blood tests of pilot study participants. The results will help to inform the design of additional clinical trials.

Lipoic acid was determined to be safe and well-tolerated by pilot study participants. Stomach upset was the most frequent side effect.


Story Source:

Materials provided by Oregon Health & Science University. Original written by Erik Robinson. Note: Content may be edited for style and length.


Journal Reference:

  1. Rebecca Spain, Katherine Powers, Charles Murchison, Elizabeth Heriza, Kimberly Winges, Vijayshree Yadav, Michelle Cameron, Ed Kim, Fay Horak, Jack Simon, Dennis Bourdette. Lipoic acid in secondary progressive MS. Neurology - Neuroimmunology Neuroinflammation, 2017; 4 (5): e374 DOI: 10.1212/NXI.0000000000000374

Cite This Page:

Oregon Health & Science University. "Multiple sclerosis: Patients may benefit from over-the-counter therapy." ScienceDaily. ScienceDaily, 30 June 2017. <www.sciencedaily.com/releases/2017/06/170630105055.htm>.
Oregon Health & Science University. (2017, June 30). Multiple sclerosis: Patients may benefit from over-the-counter therapy. ScienceDaily. Retrieved October 8, 2024 from www.sciencedaily.com/releases/2017/06/170630105055.htm
Oregon Health & Science University. "Multiple sclerosis: Patients may benefit from over-the-counter therapy." ScienceDaily. www.sciencedaily.com/releases/2017/06/170630105055.htm (accessed October 8, 2024).

Explore More

from ScienceDaily

RELATED STORIES