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Possible therapeutic target for regulating body weight

Over-expression of GTRAP3-18 gene could be related to obesity in humans

Date:
October 4, 2017
Source:
Federation of American Societies for Experimental Biology
Summary:
A new study reveals a novel gene involved in maintaining body weight.
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A new study published online in The FASEB Journal reveals a novel gene involved in maintaining body weight. Specifically, the study suggests that GTRAP3-18 interacts with pro-opiomelanocortin (POMC) in the hypothalamus to regulate food intake and blood glucose levels. Inhibiting the interaction between GTRAP3-18 and POMC might be a strategy for treating leptin/insulin resistance in patients with obesity and/or type 2 diabetes.

"Eating too much or too little could actually be a genetic problem, rather than an insulin issue," said Toshio Nakaki, M.D., Ph.D., a researcher in the Department of Pharmacology, Teikyo University School of Medicine, in Tokyo, Japan. "Drugs targeting the GTRAP3-18 gene could be therapeutic for obesity or appetite-related disorders."

Nakaki and colleagues analyzed a group of mice defective in the GTRAP3-18 gene. The GTRAP3-18-deficient mice were lean as compared with wild type mice. The leanness was due to neither increased locomotive activity nor basal metabolism, but rather a dysregulation of feeding behavior, or hypophagia. The GTRAP3-18-deficient mice also displayed hypoglycemia.

"This revealing investigation opens a new window on what is likely to be a key regulatory loop in the food intake-weight control axis, with considerable therapeutic potential," said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal.


Story Source:

Materials provided by Federation of American Societies for Experimental Biology. Note: Content may be edited for style and length.


Journal Reference:

  1. Koji Aoyama, Wattanaporn Bhadhprasit, Masahiko Watabe, Fan Wang, Nobuko Matsumura, Toshio Nakaki. GTRAP3-18 regulates food intake and body weight by interacting with pro-opiomelanocortin. The FASEB Journal, 2017; fj.201700421R DOI: 10.1096/fj.201700421R

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Federation of American Societies for Experimental Biology. "Possible therapeutic target for regulating body weight." ScienceDaily. ScienceDaily, 4 October 2017. <www.sciencedaily.com/releases/2017/10/171004101441.htm>.
Federation of American Societies for Experimental Biology. (2017, October 4). Possible therapeutic target for regulating body weight. ScienceDaily. Retrieved May 29, 2024 from www.sciencedaily.com/releases/2017/10/171004101441.htm
Federation of American Societies for Experimental Biology. "Possible therapeutic target for regulating body weight." ScienceDaily. www.sciencedaily.com/releases/2017/10/171004101441.htm (accessed May 29, 2024).

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