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Cluster of resistant tuberculosis pathogen discovered

Date:
January 9, 2018
Source:
University of Zurich
Summary:
Between February and November 2016, researchers discovered a multidrug-resistant Mycobacterium tuberculosis in eight refugees arriving in Europe from the Horn of Africa. The analyses provided an impulse for launching a transnational investigation and developing a pan-European alerting system.
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Between February and November 2016, the Institute of Medical Microbiology at the University of Zurich discovered a multidrug-resistant Mycobacterium tuberculosis in eight refugees arriving in Europe from the Horn of Africa. The analyses provided an impulse for launching a transnational investigation and developing a pan-European alerting system.

Resistant tuberculosis pathogens are a regular part of the day-to-day business at the Swiss National Center for Mycobacteria (NZM) at the University of Zurich. And yet, the Mycobacterium tuberculosis found in a Somali asylum seeker in the refugee center in Chiasso in February 2016 was extraordinary: "These bacteria exhibited a new combination of resistance mutations against four different antibiotics that had never before been described," says Peter Keller, Head of Diagnostics at NZM, who identified the germ. The multidrug resistance makes it necessary for people carrying these bacteria to be isolated and undergo intravenous drug treatment at a hospital for several months.

In the months following the discovery, the same resistant germ was also observed in further patients, all of whom had migrated to Europe from countries on the Horn of Africa. In total, the NZM identified the pathogen in eight refugees from Somalia, Eritrea, and Djibouti between February and November 2016. Thanks to the rapid detection and the isolation measures, no further people were infected in Switzerland.

Alert issued and preventive measures

This unusual build-up prompted the management of NZM and of the Federal Office of Public Health (FOPH) to alert their colleagues across Europe. At the same time, the German reference laboratory in Borstel near Hamburg also registered a case with the same pathogen. The NZM then made their molecular-biological data available to the European Center for Disease Prevention and Control (ECDC) to enable their team to identify further possible cases in the EU. In the course of these analyses, the European tuberculosis reference laboratories identified a total of 21 cases in a cross-border collaboration. As with the cases in Switzerland, these patients had also come from the Horn of Africa or Sudan.

Thanks to the alert, the pathogen was prevented from spreading further, and the authorities also took preventive measures: "The extraordinary case led to the development of a European alerting organization for dangerous tuberculosis pathogens," says Peter Keller, who initiated the European analyses. He is the corresponding author of the wide-reaching study, in which multiple European centers are involved and which was published in the journal Lancet Infectious Diseases.

Chain of infection reconstructed

Molecular-genetic analyses and interviews with patients made it possible for the researchers to partially reconstruct the chain of infection. The data indicates that the tuberculosis pathogen spread among migrants in a refugee camp near Bani Walid in Libya. The overcrowded camp, some 180 kilometers southeast of Tripoli, is notorious for its poor hygiene and inhumane conditions. Several of the patients diagnosed with this particular resistant Mycobacterium tuberculosis had come through this camp on their way to Europe.

Rapid test developed

It is no longer possible to identify with any degree of certainty the first carrier or who introduced the bacteria to the camp. Scientists believe that the pathogen originated in northern Somalia, where it is likely to have developed the dangerous new combination of resistances as a result of mutations. Genetic analyses have allowed researchers to develop a rapid PCR test. The test can be used in suspected cases of this Mycobacterium tuberculosis and the results are obtained in a matter of hours.


Story Source:

Materials provided by University of Zurich. Note: Content may be edited for style and length.


Journal Reference:

  1. Timothy M Walker, Matthias Merker, Astrid M Knoblauch, Peter Helbling, Otto D Schoch, Marieke J van der Werf, Katharina Kranzer, Lena Fiebig, Stefan Kröger, Walter Haas, Harald Hoffmann, Alexander Indra, Adrian Egli, Daniela M Cirillo, Jérôme Robert, Thomas R Rogers, Ramona Groenheit, Anne T Mengshoel, Vanessa Mathys, Marjo Haanperä, Dick van Soolingen, Stefan Niemann, Erik C Böttger, Peter M Keller, Korkut Avsar, Christoph Bauer, Enos Bernasconi, Emanuele Borroni, Sergio Brusin, Mireia Coscollá Dévis, Derrick W. Crook, Martin Dedicoat, Margaret Fitzgibbon, Sébastien Gagneux, Francisca Geiger, Jean-Paul Guthmann, David Hendrickx, Sabine Hoffmann-Thiel, Jakko van Ingen, Sarah Jackson, Katia Jaton, Christoph Lange, Jessica Mazza Stalder, Joan O'Donnell, Onya Opota, Tim E.A. Peto, Benjamin Preiswerk, Emma Roycroft, Mariko Sato, Regina Schacher, Bettina Schulthess, E. Grace Smith, Hanna Soini, Wladimir Sougakoff, Elisa Tagliani, Christian Utpatel, Nicolas Veziris, Christiane Wagner-Wiening, Mark Witschi. A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study. The Lancet Infectious Diseases, 2018; DOI: 10.1016/S1473-3099(18)30004-5

Cite This Page:

University of Zurich. "Cluster of resistant tuberculosis pathogen discovered." ScienceDaily. ScienceDaily, 9 January 2018. <www.sciencedaily.com/releases/2018/01/180109112426.htm>.
University of Zurich. (2018, January 9). Cluster of resistant tuberculosis pathogen discovered. ScienceDaily. Retrieved December 14, 2024 from www.sciencedaily.com/releases/2018/01/180109112426.htm
University of Zurich. "Cluster of resistant tuberculosis pathogen discovered." ScienceDaily. www.sciencedaily.com/releases/2018/01/180109112426.htm (accessed December 14, 2024).

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