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Brain protein changes could explain how concussions affect patients

Date:
January 17, 2018
Source:
American Chemical Society
Summary:
Traumatic brain injuries, whether suffered from a blow on the football field or the battle field, can be devastating, leading to disability and shortened lives. However, little is known about how different levels of injury and time affect the brain, hindering efforts to develop effective treatments. Scientists now report results from rodent studies showing that signaling molecules are likely involved in mild cases, also known as concussions.
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Traumatic brain injuries, whether suffered from a blow on the football field or the battle field, can be devastating, leading to disability and shortened lives. However, little is known about how different levels of injury and time affect the brain, hindering efforts to develop effective treatments. Scientists now report results from rodent studies in ACS' Journal of Proteome Research showing that signaling molecules are likely involved in mild cases, also known as concussions.

In 2013, U.S. emergency rooms received around 2.8 million patients with traumatic brain injuries, with nearly 50,000 patients dying, according to the U.S. Centers for Disease Control and Prevention. Brain injuries can be classified as mild, moderate or severe, with mild injuries, or concussions, representing about 75 percent of cases. Some people recover completely from such injuries, while others experience lasting disability or dementia, particularly if the patient has experienced repeated concussions. Previous proteomic studies in humans with brain injuries didn't control for the cause, while results in mice examined the effects of time since injury or repeated injury, but not both. In this proteomic study, Jianyun Yu, Hu Zhou and colleagues assessed brain protein levels after one or more concussions in rodents at multiple timepoints.

To perform the analysis, the researchers divided 27 rodents into nine groups: one day, seven days or six months after either no concussions, a single concussion or three concussions on three consecutive days. The researchers performed proteomic analysis on the brain samples using tandem mass spectrometry, identifying clusters of proteins that seemed to increase or decrease depending on injury severity or time since injury. Interestingly, molecules involved in the cAMP signaling pathway, which helps regulate heart rate, stress levels and memory, appear to play an important role in the mediation of brain injury and recovery.


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Journal Reference:

  1. Hai Song, Shanhua Fang, Jing Gao, Jiaxong Wang, Zhenzhen Cao, Zeyun Guo, Qiongping Huang, Yongqang Qu, Hu Zhou, Jianyun Yu. Quantitative Proteomic Study Reveals Up-Regulation of cAMP Signaling Pathway-Related Proteins in Mild Traumatic Brain Injury. Journal of Proteome Research, 2017; DOI: 10.1021/acs.jproteome.7b00618

Cite This Page:

American Chemical Society. "Brain protein changes could explain how concussions affect patients." ScienceDaily. ScienceDaily, 17 January 2018. <www.sciencedaily.com/releases/2018/01/180117164000.htm>.
American Chemical Society. (2018, January 17). Brain protein changes could explain how concussions affect patients. ScienceDaily. Retrieved May 30, 2024 from www.sciencedaily.com/releases/2018/01/180117164000.htm
American Chemical Society. "Brain protein changes could explain how concussions affect patients." ScienceDaily. www.sciencedaily.com/releases/2018/01/180117164000.htm (accessed May 30, 2024).

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