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Scorpion venom to shuttle drugs into the brain

Date:
November 15, 2018
Source:
Institute for Research in Biomedicine (IRB Barcelona)
Summary:
Biologists have described the capacity of a small protein (a peptide) derived from chlorotoxin, found in scorpion venom (Giant Yellow Israeli scorpion), to carry drugs across the blood-brain barrier (BBB).
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The Peptides and Proteins lab at the Institute for Research in Biomedicine (IRB Barcelona) has published a paper in Chemical Communications describing the capacity of a small protein (a peptide) derived from chlorotoxin, found in scorpion venom (Giant Yellow Israeli scorpion), to carry drugs across the blood-brain barrier (BBB).

The barrier serves to protect the brain from toxic substances, but it also prevents many potential drugs for the treatment of neurological diseases and tumours from entering this organ. "About 98% of drugs that could have therapeutic applications cannot be used because they cannot cross this barrier," explains the head of the lab, Ernest Giralt.

The researchers have chemically synthesised chlorotoxin and a series of analogues that retain some of the properties ofas the parent peptide. They have studied the efficiency of these compounds in cell models of the BBB and have demonstrated that the peptide called MiniCTX3 has the capacity to transport compounds of different nature across the BBB "with great efficiency". Animal venoms for the brain

In the same way that traditional medicine uses natural products such as plants and flowers to treat a range of diseases, the IRB Barcelona lab has sought inspiration from venoms with the objective of identifying peptide shuttles. "Our goal is to enable drugs to enter the brain and to do this we bind them to peptides specifically designed to cross the BBB. The conjugation of these drugs to the shuttles would improve their efficacy," says Meritxell Teixidó, co-leader of the research. "There are only two or three groups worldwide devoted to shuttle peptides. We are working on a number of strategies and one of them is venoms," says Giralt.

In previous studies, these scientists inspired in a peptide from bee venom, namely apamin, had made some chemical modifications and obtained a shuttle with BBB permeability.

After these positive results, the lab wanted to address whether venoms could provide a universal source of peptide shuttles. "Thousands of venoms that hold millions of peptides with the shuttle potential have been described. We chose chlorotoxin because it has already been reported that it acts like a toxin in the brain," explains Teixidó.

This study is another example of ground-breaking research finding inspiration in nature and it has produced another shuttle that can enhance drug transport into the brain.


Story Source:

Materials provided by Institute for Research in Biomedicine (IRB Barcelona). Note: Content may be edited for style and length.


Journal Reference:

  1. Cristina Díaz-Perlas, Monica Varese, Salvador Guardiola, Jesús García, Macarena Sánchez-Navarro, Ernest Giralt, Meritxell Teixidó. From venoms to BBB-shuttles. MiniCTX3: a molecular vector derived from scorpion venom. Chemical Communications, 2018; 54 (90): 12738 DOI: 10.1039/C8CC06725B

Cite This Page:

Institute for Research in Biomedicine (IRB Barcelona). "Scorpion venom to shuttle drugs into the brain." ScienceDaily. ScienceDaily, 15 November 2018. <www.sciencedaily.com/releases/2018/11/181115115319.htm>.
Institute for Research in Biomedicine (IRB Barcelona). (2018, November 15). Scorpion venom to shuttle drugs into the brain. ScienceDaily. Retrieved July 15, 2024 from www.sciencedaily.com/releases/2018/11/181115115319.htm
Institute for Research in Biomedicine (IRB Barcelona). "Scorpion venom to shuttle drugs into the brain." ScienceDaily. www.sciencedaily.com/releases/2018/11/181115115319.htm (accessed July 15, 2024).

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