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Gout treatment may help prevent obesity-related type 2 diabetes

Date:
April 2, 2019
Source:
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development
Summary:
The drug colchicine, used to treat the arthritic condition gout, could potentially reduce complications accompanying metabolic syndrome, a combination of high blood pressure, high blood sugar and other conditions that increase the risk of heart disease and type 2 diabetes.
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The drug colchicine, used to treat the arthritic condition gout, could potentially reduce complications accompanying metabolic syndrome, a combination of high blood pressure, high blood sugar and other conditions that increase the risk of heart disease and type 2 diabetes, according to researchers at the National Institutes of Health. Their study appears in Diabetes, Endocrinology, and Metabolism.

Previous studies have indicated that the system-wide inflammation that occurs in obesity plays a role in the development of type 2 diabetes. In the current study, researchers led by Jack A. Yanovski, M.D., Ph.D., of NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) randomly assigned 21 study participants to received colchicine twice a day for 3 months, while 19 participants received a placebo. Colchicine suppresses a multi-protein complex called NLRP3, which triggers the inflammation seen in obesity.

Researchers looked at several measures that reflect how well insulin works in the body to clear sugar from the blood (insulin resistance). There was no difference between the two groups in insulin resistance determined by one measure of insulin use (the frequently sampled, insulin-modified intravenous glucose tolerance test). However, the colchicine group showed improvement on the Homeostatic Model Assessment of Insulin Resistance test, which also estimates how much insulin is needed to keep blood sugar at a normal level while fasting. Those in the colchicine group also scored lower on a blood test of C-reactive protein and other tests that indicate inflammation. The authors concluded that larger studies are needed to determine if colchicine could prevent the development of type 2 diabetes in people with metabolic syndrome.


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Materials provided by NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development. Note: Content may be edited for style and length.


Journal Reference:

  1. Andrew P. Demidowich, Jordan A. Levine, Ginikanwa I. Onyekaba, Shahzaib M. Khan, Kong Y. Chen, Sheila M. Brady, Miranda M. Broadney, Jack A. Yanovski. Effects of Colchicine in Adults with Metabolic Syndrome: A Pilot Randomized Controlled Trial. Diabetes, Obesity and Metabolism, 2019; DOI: 10.1111/dom.13702

Cite This Page:

NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development. "Gout treatment may help prevent obesity-related type 2 diabetes." ScienceDaily. ScienceDaily, 2 April 2019. <www.sciencedaily.com/releases/2019/04/190402092233.htm>.
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development. (2019, April 2). Gout treatment may help prevent obesity-related type 2 diabetes. ScienceDaily. Retrieved July 17, 2024 from www.sciencedaily.com/releases/2019/04/190402092233.htm
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development. "Gout treatment may help prevent obesity-related type 2 diabetes." ScienceDaily. www.sciencedaily.com/releases/2019/04/190402092233.htm (accessed July 17, 2024).

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