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Put down the protein shake: Variety of protein better for health

Popular protein great for increasing muscle mass, but could reduce your life-span -- researchers say to vary protein intake

April 30, 2019
University of Sydney
Researchers have examined whether there are any ongoing ramifications or potential side-effects from long-term high protein intake or from consuming certain types of amino acids.

Amino acids have long been touted by the fitness and bodybuilding communities for their muscle building benefits. From ultra-bulk protein powders to lean mass-promoting snack bars, there's no shortage of products available for those seeking a muscle boost.

However, protein's popularity has also meant that less attention has been paid to researching its potentially negative side-effects.

Published today in Nature Metabolism, new research led by academics from the University of Sydney's Charles Perkins Centre, Professor Stephen Simpson and Dr Samantha Solon-Biet, suggests that while delivering muscle-building benefits, excessive consumption of branched-chain amino acids (BCAAs) may reduce lifespan, negatively impact mood and lead to weight gain.

BCAAs great for adding muscle mass, but science says you could pay for it later

Dr Solon-Biet's research has investigated the complex role nutrition plays in mediating various aspects of metabolic health, reproduction, appetite and ageing.

"While diets high in protein and low in carbohydrates were shown to be beneficial for reproductive function, they had detrimental effects for health in mid-late life, and also led to a shortened lifespan," she explained.

"What this new research has shown is that amino acid balance is important -- it's best to vary sources of protein to ensure you're getting the best amino acid balance."

BCAAs could influence mood -- and lead to overeating

The current research examined the impacts that dietary BCAAs and other essential amino acids such as tryptophan had on the health and body composition of mice.

"Supplementation of BCAAs resulted in high levels of BCAAs in the blood which competed with tryptophan for transport into the brain," explained Academic Director of the Charles Perkins Centre's and researcher from the School of Life and Environmental Sciences Professor Stephen Simpson.

"Tryptophan is the sole precursor for the hormone serotonin, which is often called the 'happiness chemical' for its mood-enhancing effects and its role in promoting sleep. But serotonin does more than this, and therein lay the problem," he said.

"This then lowered serotonin levels in the brain, which in turn was a potent signal to increase appetite. The serotonin decrease caused by excess BCAA intake led to massive overeating in our mice, which became hugely obese and lived shorter lives."

Mice were fed double the normal amount of BCAAs (200%), the standard amount (100%), half (50%) or one fifth (20%) for life. Mice who were fed 200% BCAAs increased their food intake, resulting in obesity and a shortened lifespan.

Increase protein variety for health benefits

Qualified dietitian and public health nutritionist from the University of Sydney's School of Life and Environmental Sciences Dr Rosilene Ribeiro recommends eating a wide-range of proteins.

It's important to vary protein sources in order to get a variety of essential amino acids, through a healthy and balanced diet rich in fibre, vitamins and minerals.

BCAAs are essential amino acids present in protein-containing foods, with red meat and dairy being the richest sources. Chicken, fish and eggs are also nutritious sources of BCAAs.

Vegetarians can find BCAAs in beans, lentils, nuts and soy proteins.

Foods rich in tryptophan include seeds and nuts, soy beans, cheese, chicken,turkey and interestingly, crocodile.

About BCAAs

BCAAs are a group of three essential amino acids: leucine, isoleucine and valine, and are most commonly found in red meat and dairy. Whey protein -- the most popular form of fitness protein -- is made from dairy by-products and contains high levels of BCAA.

Story Source:

Materials provided by University of Sydney. Note: Content may be edited for style and length.

Journal Reference:

  1. Samantha M. Solon-Biet, Victoria C. Cogger, Tamara Pulpitel, Devin Wahl, Ximonie Clark, Elena E. Bagley, Gabrielle C. Gregoriou, Alistair M. Senior, Qiao-Ping Wang, Amanda E. Brandon, Ruth Perks, John O’Sullivan, Yen Chin Koay, Kim Bell-Anderson, Melkam Kebede, Belinda Yau, Clare Atkinson, Gunbjorg Svineng, Tim Dodgson, Jibran A. Wali, Matthew D. W. Piper, Paula Juricic, Linda Partridge, Adam J. Rose, David Raubenheimer, Gregory J. Cooney, David G. Le Couteur, Stephen J. Simpson. Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature Metabolism, 2019; DOI: 10.1038/s42255-019-0059-2

Cite This Page:

University of Sydney. "Put down the protein shake: Variety of protein better for health." ScienceDaily. ScienceDaily, 30 April 2019. <>.
University of Sydney. (2019, April 30). Put down the protein shake: Variety of protein better for health. ScienceDaily. Retrieved April 22, 2024 from
University of Sydney. "Put down the protein shake: Variety of protein better for health." ScienceDaily. (accessed April 22, 2024).

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