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Broken brain cells repaired in dementia mouse model

If translated to humans, results suggest new directions for combating cognitive decline in elderly

Date:
May 27, 2019
Source:
Society for Neuroscience
Summary:
Dysfunctional neurons in the hippocampus of adult female mice modeling dementia can be repaired and reconnected to distant parts of the brain, reports a new study. The similarity between the mouse model and the human condition underscores the therapeutic potential of targeting these cells in dementia patients.
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Dysfunctional neurons in the hippocampus of adult female mice modeling dementia can be repaired and reconnected to distant parts of the brain, reports a new study published in JNeurosci. The similarity between the mouse model and the human condition underscores the therapeutic potential of targeting these cells in dementia patients.

The hippocampus generates new brain cells throughout life and is implicated in neurodegenerative diseases. María Llorens-Martín and colleagues at the Centro de Biología Molecular "Severo Ochoa" (CBMSO, CSIC-UAM) used a mouse model of frontotemporal dementia to investigate the effects of the disease on dentate granule cells.

Compared to control subjects, the researchers observed strikingly similar alterations in newborn neurons from their mouse model and from human brain tissue of patients with frontotemporal dementia. In mice, chemically activating the cells and placing animals in a stimulating environment with running wheels and toys reversed the alterations and restore some of the connectivity disrupted by dementia. If translated to humans, these results suggest potential new directions for combating cognitive decline in the elderly.


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Materials provided by Society for Neuroscience. Note: Content may be edited for style and length.


Journal Reference:

  1. J Terreros-Roncal, M Flor-García, E. P. Moreno-Jiménez, N Pallas-Bazarra, A Rábano, N Sah, H van Praag, D Giacomini, AF Schinder, J Ávila, M Llorens-Martín. Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia. The Journal of Neuroscience, 2019; 2724-18 DOI: 10.1523/JNEUROSCI.2724-18.2019

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Society for Neuroscience. "Broken brain cells repaired in dementia mouse model." ScienceDaily. ScienceDaily, 27 May 2019. <www.sciencedaily.com/releases/2019/05/190527143255.htm>.
Society for Neuroscience. (2019, May 27). Broken brain cells repaired in dementia mouse model. ScienceDaily. Retrieved April 15, 2024 from www.sciencedaily.com/releases/2019/05/190527143255.htm
Society for Neuroscience. "Broken brain cells repaired in dementia mouse model." ScienceDaily. www.sciencedaily.com/releases/2019/05/190527143255.htm (accessed April 15, 2024).

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