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Early onset of menstruation associated with higher risk of type 2 diabetes

Large-scale study confirms association may be partially mediated by body mass index

Date:
July 31, 2019
Source:
The North American Menopause Society (NAMS)
Summary:
Diabetes is a global health concern expected to affect 693 million people worldwide by 2045. It's been well documented how diet and exercise influence risk of type 2 diabetes; however, a new study suggests that early menarche also is associated with a higher risk, but body mass index (BMI) may mediate this association.
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Diabetes is a global health concern expected to affect 693 million people worldwide by 2045. It's been well documented how diet and exercise influence risk of type 2 diabetes; however, a new study suggests that early menarche also is associated with a higher risk, but body mass index (BMI) may mediate this association. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).

Type 2 diabetes mellitus has become one of the most common diseases worldwide. In 2015, it affected nearly 8.8% of people aged 20 to 79 globally, and by 2040, it is expected to affect 10.4%. With so many people affected, it is not surprising how much research has been devoted to identifying determinants of the disease in order to prevent its development. Various lifestyle and environmental factors have already been confirmed, but there is also growing evidence pointing to some physiologic factors.

A new study analyzing more than 15,000 postmenopausal women in China has found that women who begin menstruating at an earlier age have a higher risk of developing type 2 diabetes. More specifically, each year of delay in menarche age correlated with a 6% lower risk of type 2 diabetes.

Although this is not the first study to suggest the association between menarche and diabetes, it provides added evidence regarding the increased risk, as well as the fact that BMI can partially mediate the association and the proportion of that effect is 28%.

"This study of rural Chinese women indicates that the average age of menarche is delayed relative to western countries at 16.1 years and is linked with lower risk of type 2 diabetes. Earlier onset of menses (14 y) was associated with diabetes in later life, likely driven by adult BMI. Other factors such as nutrition and BMI in childhood may also play a role in this association," says Dr. Stephanie Faubion, NAMS medical director.


Story Source:

Materials provided by The North American Menopause Society (NAMS). Note: Content may be edited for style and length.


Journal Reference:

  1. Lulu Zhang, Yuqian Li, Chongjian Wang, Zhenxing Mao, Wen Zhou, Zhongyan Tian, Xiaokang Dong, Haiqing Zhang, Xiu Yang, Mengying Fan, Linlin Li. Early menarche is associated with an increased risk of type 2 diabetes in rural Chinese women and is partially mediated by BMI. Menopause, 2019; 1 DOI: 10.1097/GME.0000000000001385

Cite This Page:

The North American Menopause Society (NAMS). "Early onset of menstruation associated with higher risk of type 2 diabetes." ScienceDaily. ScienceDaily, 31 July 2019. <www.sciencedaily.com/releases/2019/07/190731102206.htm>.
The North American Menopause Society (NAMS). (2019, July 31). Early onset of menstruation associated with higher risk of type 2 diabetes. ScienceDaily. Retrieved June 14, 2024 from www.sciencedaily.com/releases/2019/07/190731102206.htm
The North American Menopause Society (NAMS). "Early onset of menstruation associated with higher risk of type 2 diabetes." ScienceDaily. www.sciencedaily.com/releases/2019/07/190731102206.htm (accessed June 14, 2024).

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