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New study identifies unique type of microglia associated with stroke in the I/R injured brain

Date:
October 24, 2022
Source:
Ulsan National Institute of Science and Technology(UNIST)
Summary:
Medical researchers have identified a new type of microglia associated with stroke in the ischemia/reperfusion (I/R) injured brain.
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A research team, affiliated with UNIST has identified a new type of microglia associated with stroke in the ischemia/reperfusion (I/R) injured brain. This breakthrough has been led by Professor Sung Ho Park and his research team in the Department of Biological Sciences at UNIST, in collaboration with a research team, led by Professor Goo Taeg Oh from Ewha Womans University.

Microglia, the primary immune cells in the central nervous system (CNS), are known to eliminate unwanted germs and debris and remove dying neurons. In this study, the research team classified a new type of microglia with enhanced antioxidant function and markers similar to those of disease-associated microglia (DAM), designated them as stroke-associated microglia (SAM).

Through animal experiments, the research team demonstrated that the presence of the typical antioxidant gene, Peroxiredoxin-1 (Prdx1), protects against acute I/R injury and is required for SAM activation and the consequent reduction of microglial cell death and inflammatory responses.

In addition, after performing transient middle cerebral artery occlusion (tMCAO) surgery to induce ischemic stroke in mice, the research team found that Prdx1−/− mice were more severely injured by acute I/R injury, as confirmed by TTC staining, neurological deficit scores, motor tests, and the survival rate, indicating that Prdx1 has a protective function.

"In this study, we have, for the first time, identified a specialized and distinctive type of microglia with enhanced antioxidant function in stroke mice," says Professor Park. "Prdx1-dependent SAM may be a potential biomarker and therapeutic target for protecting microglial function and treating brain I/R injury," He adds, "Although this new cluster will require further study, our findings provide a new perspective that Prdx1-mediated microglial heterogeneity is important in ischemic stroke."

This study has been jointly participated by Wonhyo Lee, a doctoral researcher within the Department of Biological Sciences at UNIST and Sinai Kim, a doctoral researcher within the Department of Life Sciences at Ewha Womans University, as first authors. Their findings have been published in the August 2022 issue of Redox Biology. This study was carried out with the support of the National Research Foundation of Korea (NRF).


Story Source:

Materials provided by Ulsan National Institute of Science and Technology(UNIST). Original written by JooHyeon Heo. Note: Content may be edited for style and length.


Journal Reference:

  1. Sinai Kim, Wonhyo Lee, Huiju Jo, Seong-Keun Sonn, Se-Jin Jeong, Seungwoon Seo, Joowon Suh, Jing Jin, Hyae Yon Kweon, Tae Kyeong Kim, Shin Hye Moon, Sejin Jeon, Jong Woo Kim, Yu Ri Kim, Eun-Woo Lee, Hwa Kyoung Shin, Sung Ho Park, Goo Taeg Oh. The antioxidant enzyme Peroxiredoxin-1 controls stroke-associated microglia against acute ischemic stroke. Redox Biology, 2022; 54: 102347 DOI: 10.1016/j.redox.2022.102347

Cite This Page:

Ulsan National Institute of Science and Technology(UNIST). "New study identifies unique type of microglia associated with stroke in the I/R injured brain." ScienceDaily. ScienceDaily, 24 October 2022. <www.sciencedaily.com/releases/2022/10/221024102523.htm>.
Ulsan National Institute of Science and Technology(UNIST). (2022, October 24). New study identifies unique type of microglia associated with stroke in the I/R injured brain. ScienceDaily. Retrieved December 7, 2024 from www.sciencedaily.com/releases/2022/10/221024102523.htm
Ulsan National Institute of Science and Technology(UNIST). "New study identifies unique type of microglia associated with stroke in the I/R injured brain." ScienceDaily. www.sciencedaily.com/releases/2022/10/221024102523.htm (accessed December 7, 2024).

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