New! Sign up for our free email newsletter.
Science News
from research organizations

New study shows anti-inflammatory drugs as a promising target for Alzheimer's disease

Date:
July 17, 2023
Source:
University of Kentucky
Summary:
A recent study centers around the idea that various anti-inflammatory drugs could be effective treatments for Alzheimer's disease. This study focused on a protein known as p38. Many labs have been working with this protein as a potential target for drug development to treat Alzheimer's disease and other conditions with neuroinflammatory dysfunction.
Share:
FULL STORY

A recent study from the lab of the University of Kentucky's Sanders-Brown Center on Aging Director Linda Van Eldik, Ph.D., has been published in PLOS ONE. The work centers around the idea that various anti-inflammatory drugs could be effective treatments for Alzheimer's disease (AD). This study focused on a protein known as p38. Many labs have been working with this protein as a potential target for drug development to treat Alzheimer's disease and other conditions with neuroinflammatory dysfunction.

Van Eldik and her team used genetic techniques to stop the production of p38 in the major immune cell type within the brain, the microglia. They tested the effects of this in an early-stage mouse model of AD to determine whether it would alter the trajectory of amyloid plaque formation, a major component of AD pathology. While the plaques themselves were not affected, the amount of microglia in proximity to these plaques was decreased, suggesting that suppression of microglial p38 may affect their interactions with aspects of AD pathology.

Some classes of anti-inflammatory drugs include p38 inhibitors, which are currently under clinical development and have shown encouraging results during recent human clinical trials. However, it is still not clear when during the disease process these p38 inhibitors should be administered and whether long-term suppression of p38 is harmful. The findings reported by the Van Eldik lab indicate that early inhibition of p38 may be able to alter interactions between brain immune cells and AD pathology, and they suggest that long-term suppression of p38 does not cause noticeable adverse effects.


Story Source:

Materials provided by University of Kentucky. Original written by Hillary Smith. Note: Content may be edited for style and length.


Journal Reference:

  1. David J. Braun, Hilaree N. Frazier, Verda A. Davis, Meggie J. Coleman, Colin B. Rogers, Linda J. Van Eldik. Early chronic suppression of microglial p38α in a model of Alzheimer’s disease does not significantly alter amyloid-associated neuropathology. PLOS ONE, 2023; 18 (5): e0286495 DOI: 10.1371/journal.pone.0286495

Cite This Page:

University of Kentucky. "New study shows anti-inflammatory drugs as a promising target for Alzheimer's disease." ScienceDaily. ScienceDaily, 17 July 2023. <www.sciencedaily.com/releases/2023/07/230717115837.htm>.
University of Kentucky. (2023, July 17). New study shows anti-inflammatory drugs as a promising target for Alzheimer's disease. ScienceDaily. Retrieved June 19, 2024 from www.sciencedaily.com/releases/2023/07/230717115837.htm
University of Kentucky. "New study shows anti-inflammatory drugs as a promising target for Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2023/07/230717115837.htm (accessed June 19, 2024).

Explore More

from ScienceDaily

RELATED STORIES