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Cells putting on a face

Formation of branchial arches modeling facial primordium

Date:
April 11, 2024
Source:
Kyoto University
Summary:
Neural crest cells -- embryonic pluripotent cells within the facial primordium -- may be necessary for forming proper animal facial structures. Researchers have produced neural crest cell-rich aggregates from human pluripotent stem cells and developed a method to differentiate them in cell populations with a branchial arch-like gene expression pattern.
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Mother Nature is an artist, but her craft of creating animal faces requires more than a paintbrush and palette. Such highly complex shapes originate from their respective transient neural crest cells.

These embryonic pluripotent cells within the facial primordium -- the early development form -- may be necessary for forming proper facial structures. However, analyzing the molecular mechanisms in such early stages of development poses many technical challenges.

Now, a group of Kyoto University researchers have produced neural crest cell-rich aggregates from human pluripotent stem cells and developed a method to differentiate them in cell populations with a branchial arch-like gene expression pattern.

"After the cell populations differentiate into precursors of maxillary and mandibular cells in response to external signalling factors, these populations spontaneously form patterns of the facial primordium," explains Yusuke Seto of KyotoU's Institute for Medical and Biological Research.

This cartilage-like structure, reminiscent of Meckel's cartilage, is formed locally within the aggregates.

"We aim to establish a model for studying early facial development by using the properties of human pluripotent stem cells to generate in vitro tissue resembling the bronchial arch of the primordial face," adds Ryoma Ogihara, also of the Institute.

Researchers are examining the various developmental processes that cause interspecific and individual differences in facial structure to explain conditions such as craniofacial disorders.

"Using our in vitro model could help us better understand and control signal integration during the fate determination of the branchial arch and cartilage formation in the face and elsewhere. We hope our technology can contribute to the development of cellular materials for new regenerative medicine," adds Mototsugu Eiraku, also of the Institute.


Story Source:

Materials provided by Kyoto University. Note: Content may be edited for style and length.


Journal Reference:

  1. Yusuke Seto, Ryoma Ogihara, Kaori Takizawa, Mototsugu Eiraku. In vitro induction of patterned branchial arch-like aggregate from human pluripotent stem cells. Nature Communications, 2024; 15 (1) DOI: 10.1038/s41467-024-45285-0

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Kyoto University. "Cells putting on a face." ScienceDaily. ScienceDaily, 11 April 2024. <www.sciencedaily.com/releases/2024/04/240411212758.htm>.
Kyoto University. (2024, April 11). Cells putting on a face. ScienceDaily. Retrieved May 22, 2024 from www.sciencedaily.com/releases/2024/04/240411212758.htm
Kyoto University. "Cells putting on a face." ScienceDaily. www.sciencedaily.com/releases/2024/04/240411212758.htm (accessed May 22, 2024).

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