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Odor-causing bacteria in armpits targeted using bacteriophage-derived lysin

Bacteriophage therapy could be developed based on study's results

Date:
April 23, 2024
Source:
Osaka Metropolitan University
Summary:
A research team has synthesized a lysin that during in vitro experiments targets bacteria responsible for producing odors in human armpits.
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Body odor from the armpits comes from bacteria metabolizing sweat produced by the apocrine glands. These bacteria are native to our skin, but the odors produced differ among people. Generally, people use deodorants on their armpits, but perhaps there is a way to get rid of the bacteria.

To find out, a research team led by Osaka Metropolitan University Professor Satoshi Uematsu and Associate Professor Kosuke Fujimoto at the Graduate School of Medicine collected body fluid samples from the armpits of 20 men that were deemed healthy. In advance, a subjective olfactory panel classified them into two types of odors, with 11 having a more noticeable smell. The researchers analyzed the matter produced from bacterial metabolism and the DNA of the skin microflora and found an increased presence of odor-causing precursors in those 11 samples along with a proliferation of Staphylococcus hominis bacteria.

The team then synthesized a lysin from a bacteriophage, or virus that attacks bacteria, that infects S. hominis. During in vitro experiments, this lysin was found to target only S. hominis, not other bacteria normally present on the skin.

"We performed a large-scale metagenomic analysis of the skin microflora using the SHIROKANE supercomputer at the University of Tokyo and found that S. hominis is important in the development of odor," said Assistant Professor Miho Uematsu in the Department of Immunology and Genomics. "The identification of the lysin that attacks S. hominis is also the result of the comprehensive genome analysis."

Dr. Miki Watanabe, who is part of the Department of Immunology and Genomics and the Department of Dermatology added: "Axillary [armpit] odors are one of the few dermatological disorders in which bacteria are the primary cause. Although many patients suffer from axillary odors, there are few treatment options. We believe that this study will lead to a new therapy."


Story Source:

Materials provided by Osaka Metropolitan University. Note: Content may be edited for style and length.


Journal Reference:

  1. Miki Watanabe, Miho Uematsu, Kosuke Fujimoto, Takeshi Hara, Mako Yamamoto, Daichi Miyaoka, Chieko Yokota, Yukari Kamei, Akira Sugimoto, Natsuko Kawasaki, Takato Yabuno, Noriaki Sato, Shintaro Sato, Kiyoshi Yamaguchi, Yoichi Furukawa, Daisuke Tsuruta, Fumihiro Okada, Seiya Imoto, Satoshi Uematsu. Targeted lysis of Staphylococcus hominis linked to axillary osmidrosis using bacteriophage-derived endolysin. Journal of Investigative Dermatology, 2024; DOI: 10.1016/j.jid.2024.03.039

Cite This Page:

Osaka Metropolitan University. "Odor-causing bacteria in armpits targeted using bacteriophage-derived lysin." ScienceDaily. ScienceDaily, 23 April 2024. <www.sciencedaily.com/releases/2024/04/240423113115.htm>.
Osaka Metropolitan University. (2024, April 23). Odor-causing bacteria in armpits targeted using bacteriophage-derived lysin. ScienceDaily. Retrieved May 27, 2024 from www.sciencedaily.com/releases/2024/04/240423113115.htm
Osaka Metropolitan University. "Odor-causing bacteria in armpits targeted using bacteriophage-derived lysin." ScienceDaily. www.sciencedaily.com/releases/2024/04/240423113115.htm (accessed May 27, 2024).

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