New! Sign up for our free email newsletter.
Science News
from research organizations

Revealing the dynamic choreography inside multilayer vesicles

Date:
June 26, 2024
Source:
American Chemical Society
Summary:
Our cells and the machinery inside them are engaged in a constant dance. This dance involves some surprisingly complicated choreography within the lipid bilayers that comprise cell membranes and vesicles -- structures that transport waste or food within cells. In a recent paper, researchers shed some light on how these vesicles self-assemble, knowledge that could help scientists design bio-inspired vesicles for drug-delivery or inspire them to create life-like synthetic materials.
Share:
FULL STORY

Our cells and the machinery inside them are engaged in a constant dance. This dance involves some surprisingly complicated choreography within the lipid bilayers that comprise cell membranes and vesicles -- structures that transport waste or food within cells. In a recent ACS Nano paper, Luis Mayorga and Diego Masone shed some light on how these vesicles self-assemble, knowledge that could help scientists design bio-inspired vesicles for drug-delivery or inspire them to create life-like synthetic materials.

Double-membrane vesicles have inner and outer lipid bilayers. While scientists previously predicted that these membranes fold and warp themselves into a variety of shapes, researchers could not observe the rearrangement experimentally. So, Mayorga and Masone used molecular dynamics calculations together with an algorithm developed by Bart Bruininks and colleagues to virtually "segment" the layers so they can be seen separately.

After running dozens of simulations with different vesicle sizes and lipid compositions, five common shapes were identified: oblates and prolates (elongated or flattened blobs), toroids (doughnuts), stomatocytes (cup shapes) and spheroids. This work, say the researchers, offers insight into the "unexpected inner intricacies" of how lipid bodies spontaneously self-organize.


Story Source:

Materials provided by American Chemical Society. Note: Content may be edited for style and length.


Journal Reference:

  1. Luis S. Mayorga, Diego Masone. The Secret Ballet Inside Multivesicular Bodies. ACS Nano, 2024; 18 (24): 15651 DOI: 10.1021/acsnano.4c01590

Cite This Page:

American Chemical Society. "Revealing the dynamic choreography inside multilayer vesicles." ScienceDaily. ScienceDaily, 26 June 2024. <www.sciencedaily.com/releases/2024/06/240626151947.htm>.
American Chemical Society. (2024, June 26). Revealing the dynamic choreography inside multilayer vesicles. ScienceDaily. Retrieved July 17, 2024 from www.sciencedaily.com/releases/2024/06/240626151947.htm
American Chemical Society. "Revealing the dynamic choreography inside multilayer vesicles." ScienceDaily. www.sciencedaily.com/releases/2024/06/240626151947.htm (accessed July 17, 2024).

Explore More

from ScienceDaily

RELATED STORIES