Featured Research

from universities, journals, and other organizations

Fly With Brain Tumor May Shed Light On Cancer Causing Genes

Date:
April 19, 2004
Source:
BioMed Central
Summary:
A study showing how the expression of genes changes when the brain tissue of fruit flies becomes cancerous is published this week in BMC Genomics.

A study showing how the expression of genes changes when the brain tissue of fruit flies becomes cancerous is published this week in BMC Genomics. As the function of many of these genes is conserved across evolution, the researchers expect their results will help us to understand why human brain tumors develop.

The causes of brain tumor development are largely unknown. To investigate this question, researchers from University of Basel, Switzerland and University of Freiburg, Germany, used microarray technology to compare the levels of gene expression in the heads of healthy flies and those with brain cancer.

They found significant changes in the expression levels of 321 different genes. These were involved in several different processes including metabolism, cell proliferation, gene transcription and protein translation.

"One fifth of these genes show homology to known mammalian genes involved in cancer formation," write the researchers.

The flies with cancer had mutations in the tumor-suppressor gene brain tumor (brat), which stopped the gene from functioning correctly. Inactivation of the brat gene causes the Drosophila larval brain to overgrow. The majority of larvae do not make it to adulthood - only 15% of them turn into flies. Surviving flies have large brains made up of cancerous tissue, and they normally die young.

If cells from this cancerous tissue are transplanted into a healthy fly, they grow rapidly and spread – forming secondary tumors around the fly's body. The researchers plan to use the information that they have gathered from this experiment to elucidate which of the genes upregulated in these cancer cells are responsible for the cells' metastatic behaviour.

###

This press release is based on the following article:

Transcriptional signature of an adult brain tumor in DrosophilaThomas Loop, Ronny Leemans, Urs Stiefel, Leandro Hermida, Boris Egger, Fukang Xie, Michael Primig, Ulrich Certa, Karl-Friedrick Fischbach, Heinrich Reichert, and Frank HirthBMC Genomics 2004, 5:24To be published Friday 16 April, 2004

Upon publication this article will be available free of charge, according to BMC Genomic's Open Access policy at http://www.biomedcentral.com/1471-2164/5/24


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Fly With Brain Tumor May Shed Light On Cancer Causing Genes." ScienceDaily. ScienceDaily, 19 April 2004. <www.sciencedaily.com/releases/2004/04/040416013933.htm>.
BioMed Central. (2004, April 19). Fly With Brain Tumor May Shed Light On Cancer Causing Genes. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2004/04/040416013933.htm
BioMed Central. "Fly With Brain Tumor May Shed Light On Cancer Causing Genes." ScienceDaily. www.sciencedaily.com/releases/2004/04/040416013933.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins