Featured Research

from universities, journals, and other organizations

UCSB Researchers Discover That The Cell's Endosomes Use A Surprising Transportation System

Date:
October 6, 2005
Source:
University of California - Santa Barbara
Summary:
Cells have developed a surprising transportation system for their endosomes, according to research published today in Physical Review Letters, "Dynamics and Spatial Organization of Endosomes in Mammalian Cells."

Santa Barbara, California (October 5, 2005) -- Cells have developed asurprising transportation system for their endosomes, according toresearch published today in Physical Review Letters, "Dynamics andSpatial Organization of Endosomes in Mammalian Cells."

Related Articles


By marking endosomes with fluorescent tags and watching them move inlive cells, Samir Mitragotri, a UCSB professor of chemical engineering,and graduate students Chinmay Pangarkar and Anh Tuan Dinh learned thatthe endosomes travel to the cell's nucleus using back-and-forthsymmetrical movement, rather than taking a more direct route. Thisforward and reverse motion leads to even distribution of the endosomeson microtubules.

An aster-like layout of the microtubules helps the endosomes accumulateat the nucleus. The researchers think this non-direct approach to thenucleus has evolved to allow hundreds of endosomes to bring nutrientsand molecular information to the cell's center for processing. Even ifthe cell moves or if there's increased traffic flow, there's never atraffic jam on the microtubules.

While it has long been known that endosomes travel in a bidirectionalway, it has not previously been established that the transport systemis symmetrical. The authors believe that because a number ofneurological, muscular and cardiac diseases stem from themalfunctioning of one or more proteins that regulate the transportproperties of endosomes or lysosomes, it may be possible to perform insilico and/or laboratory experiments to better understand therelationship between transport properties and pathology.

The delivery of many therapeutic agents, especially DNA and siRNA isdependent on endocytic transport. Understnading how endosomedistribution evolves is central to such therapeutic approaches.


Story Source:

The above story is based on materials provided by University of California - Santa Barbara. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Santa Barbara. "UCSB Researchers Discover That The Cell's Endosomes Use A Surprising Transportation System." ScienceDaily. ScienceDaily, 6 October 2005. <www.sciencedaily.com/releases/2005/10/051006082852.htm>.
University of California - Santa Barbara. (2005, October 6). UCSB Researchers Discover That The Cell's Endosomes Use A Surprising Transportation System. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2005/10/051006082852.htm
University of California - Santa Barbara. "UCSB Researchers Discover That The Cell's Endosomes Use A Surprising Transportation System." ScienceDaily. www.sciencedaily.com/releases/2005/10/051006082852.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
New Dinosaur Species Found in Museum Collection

New Dinosaur Species Found in Museum Collection

Reuters - Innovations Video Online (Nov. 27, 2014) A British palaeontologist has discovered a new species of dinosaur while studying fossils in a Canadian museum. Pentaceratops aquilonius was related to Triceratops and lived at the end of the Cretaceous Period, around 75 million years ago. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Tryptophan Isn't Making You Sleepy On Thanksgiving

Tryptophan Isn't Making You Sleepy On Thanksgiving

Newsy (Nov. 27, 2014) Tryptophan, a chemical found naturally in turkey meat, gets blamed for sleepiness after Thanksgiving meals. But science points to other culprits. Video provided by Newsy
Powered by NewsLook.com
Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins