Featured Research

from universities, journals, and other organizations

Sleeping Sickness Parasite Shows How Cells Divide Their Insides

Date:
November 10, 2005
Source:
Yale University
Summary:
Researchers at Yale have brought to light a mechanism that regulates the way an internal organelle, the Golgi apparatus, duplicates as cells prepare to divide, according to a report in Science Express.

Centrin (green), in a bi-lobed structure (filled arrowheads) associated with Golgi (red), shows growth of new Golgi and increasing separation from old Golgi accompanied by duplication and segregation of the bi-lobed structure. DNA is blue.
Credit: Image courtesy of Yale University

Researchers at Yale have brought to light a mechanism that regulates the way an internal organelle, the Golgi apparatus, duplicates as cells prepare to divide, according to a report in Science Express.

Graham Warren, professor of cell biology, and his colleagues at Yale study Trypanosoma brucei, the parasite that causes Sleeping Sickness. Like many parasites, it is exceptionally streamlined and has only one of each internal organelle, making it ideal for studying processes of more complex organisms that have many copies in each cell.

When thinking about how cells divide, doubling and separating DNA in chromosomes is often the focus. Equally important is the way a cell prepares its internal organelles for distribution. Warren studies the Golgi complex, a membrane compartment in the cytoplasm that delivers newly-made proteins to different membranes in the cell.

"Basal bodies in particular and centrosomes in general have been implicated in the biogenesis of a number of membrane-bound organelles," said Warren. "It prompted us to study further their role in Golgi duplication."

Warren's group has identified a new cellular structure, distinct from the basal body, involved in the duplication of the Golgi apparatus and defined by a highly-conserved protein, Centrin2. This structure has two lobes -- one at the old Golgi, the other where the new Golgi forms. Once a new Golgi has grown, the Centrin structure itself duplicates so that two complete structures, and associated Golgi, are ready to be allocated to daughter cells.

Significant recent advances in the molecular genetics of trypanosomes by Elisabetta Ullu and Christian Tschudi's group at Yale, allowed direct manipulation of protein levels using the innate RNA interference (RNAi) system.The relationship between the growing Golgi, the Centrin proteins and other cellular organelles was shown in experiments using RNAi, and visualizing the process was possible with fluorescent protein tags. How this process relates to higher organisms is the focus of present research.

###

Cynthia Y. He and Marc Pypaert of Yale were co-authors on the work, which was funded by the National Institutes of Health.

Citation: Science Express (online October 27, 2005)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Sleeping Sickness Parasite Shows How Cells Divide Their Insides." ScienceDaily. ScienceDaily, 10 November 2005. <www.sciencedaily.com/releases/2005/11/051109183548.htm>.
Yale University. (2005, November 10). Sleeping Sickness Parasite Shows How Cells Divide Their Insides. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2005/11/051109183548.htm
Yale University. "Sleeping Sickness Parasite Shows How Cells Divide Their Insides." ScienceDaily. www.sciencedaily.com/releases/2005/11/051109183548.htm (accessed July 22, 2014).

Share This




More Plants & Animals News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Michigan Plant's Goal: Flower and Die

Michigan Plant's Goal: Flower and Die

AP (July 22, 2014) An 80-year-old agave plant, which is blooming for the first and only time at a University of Michigan conservatory, will die when it's done (July 22) Video provided by AP
Powered by NewsLook.com
San Diego Zoo Welcomes New, Rare Rhino Calf

San Diego Zoo Welcomes New, Rare Rhino Calf

Reuters - US Online Video (July 21, 2014) An endangered black rhino baby is the newest resident at the San Diego Zoo. Sasha Salama reports. Video provided by Reuters
Powered by NewsLook.com
Shark Sightings a Big Catch for Cape Tourism

Shark Sightings a Big Catch for Cape Tourism

AP (July 21, 2014) A rise in shark sightings along the shores of Chatham, Massachusetts is driving a surge of eager vacationers to the beach town looking to catch a glimpse of a great white. (July 21) Video provided by AP
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins