Featured Research

from universities, journals, and other organizations

Entirely New Process In Cell RNA Discovered

Date:
May 14, 2007
Source:
Uppsala University
Summary:
Scientists have discovered an entirely new process in which short, tiny "antisense RNA" competes with the protein-producing ribosomes for starting sites for reading messenger RNA. These unexpected findings are being presented in the journal Molecular Cell.

Uppsala University scientists have discovered an entirely new process in which short, tiny “antisense RNA” competes with the protein-producing ribosomes for starting sites for reading messenger RNA. These unexpected findings are being presented in the journal Molecular Cell.

Related Articles


When cells grow and reproduce, they must constantly produce new proteins from their building blocks, 20 different amino acids. These proteins are put together by ribosomes, which move along messenger RNA molecules to read and translate information to the sequences of amino acids that determine the function of all of the proteins in the cell.

It was previously known that short, tiny control RNA, called antisense RNA, can stop the activity of genes by placing themselves so that “reading” of the code is impeded. It has been shown that this occurs in bacteria in that antisense RNA sets up base pairs with a certain messenger RNA (m-RNA) precisely where the ribosomes would start their reading.

“This is inhibits the reading. Ribosomes need single-strand RNA in order to start,” says Gerhart Wagner, professor of procaryote microbiology at Uppsala University.

In the Uppsala researchers’ study, an unexpected and entirely new mechanism was uncovered for this regulation of protein synthesis, which cannot be explained by a model in which antisense RNA blocks the ribosomes’ starting site on messenger RNA. In this case, instead, antisense RNA sets up base pairs far away from where the reading should start­-but still manages to stop the reading. It turns out that when a ribosome comes to a starting site that is “closed,” it attaches instead to an “open” site further along and waits for the proper site to become available.

“This is binding in stand-by, you might say. But we can show that antisense RNA competes with the ribosomes to be able to attach to this stand-by site as well. And if they get there first, then protein synthesis is prevented. This is something no one has seen before, and it provides a new picture of the innermost process of life,” says Gerhart Wagner.


Story Source:

The above story is based on materials provided by Uppsala University. Note: Materials may be edited for content and length.


Cite This Page:

Uppsala University. "Entirely New Process In Cell RNA Discovered." ScienceDaily. ScienceDaily, 14 May 2007. <www.sciencedaily.com/releases/2007/05/070513085709.htm>.
Uppsala University. (2007, May 14). Entirely New Process In Cell RNA Discovered. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2007/05/070513085709.htm
Uppsala University. "Entirely New Process In Cell RNA Discovered." ScienceDaily. www.sciencedaily.com/releases/2007/05/070513085709.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) — Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) — A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Reuters - Light News Video Online (Dec. 19, 2014) — Millions of monarch butterflies begin to descend onto Mexico as part of their annual migration south. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins