Featured Research

from universities, journals, and other organizations

Discovery Of A Mechanism That Regulates Cell Movement

Date:
July 23, 2008
Source:
Institute for Research in Biomedicine (IRB Barcelona)
Summary:
A mechanism that controls the movement of cells in a tissue by regulating cell adhesion has been identified. This same mechanism may be defective in diseases such as cancer and metastasis, when tumour cells lose their adhesion to neighbouring cells and migrate through the organism.

A study performed by researchers at the Institute for Research in Biomedicine (IRB Barcelona), in collaboration with researchers at the Instituto de Biologνa Molecular of the CSIC, reveal a mechanism that controls the movement of cells in a tissue by regulating cell adhesion. This same mechanism may be defective in diseases such as cancer and its metastasis, when tumour cells lose their adhesion to neighbouring cells and migrate through the organism. The results of this research have been recently published in Nature Cell Biology.

Specialists in development, Daniel Shaye, Jordi Casanova and Marta Llimargas, have studied the mechanisms that control cell movements during trachea development in the fly Drosophila. In this process, cells that initially form column of two cells deep, change their position to line up one after the other in a single file. A key element in the regulation of these movements is the amount of adhesive protein E-Cadherin located in the cellular membrane. Jordi Casanova, head of the Morphogenesis in Drosophila at IRB Barcelona, explains that "when movement starts, the levels of this protein in the cells decrease, thereby allowing them to slide one on top of the other, and once in this position the levels of this protein are re-established in order to seal the new binding alignment".

The in-depth study of this phenomenon has led to the finding that the amount of E-Cadherin on the cell surface is controlled by the trafficking of this protein inside the cell and the identification of the elements that regulate this transport. During the experiments, the researchers induced or blocked cell movement by modifying the elements that control the trafficking of adhesive protein towards the membrane. "We demonstrate a mechanism that explains how cells can change their position within a given tissue. The sequence is clear: the greater the amount of protein, the greater the adhesion and the smaller the movement", recaps Casanova.

A mechanism may be dysfunctional during cancer progression and metastases

The role of E-Cadherin in the binding between epithelial cells is universal in all animals and therefore, following logic, the researchers believe that the mechanisms that regulate the levels of this protein may also be universal. "We speculate that the regulatory mechanism that we have discovered may also be present in other developmental contexts. However, in addition, fundamental elements of the mechanism may show a dysfunction in pathological processes such as the progression of cancer and metastases", adds Casanova.

As revealed by this same researcher, the amounts of E-Cadherin and of one of the elements required for trafficking decrease in the progression of a kind of oesophagus cancer and this effect is related to the gain in tumour cell motility, which allows them to spread throughout the body more rapidly.

Researchers working on cancer will now be able to use animal models to test whether this mechanism is defective in other kinds of tumours and to study whether any of its genetic components are valid as therapeutic targets.


Story Source:

The above story is based on materials provided by Institute for Research in Biomedicine (IRB Barcelona). Note: Materials may be edited for content and length.


Cite This Page:

Institute for Research in Biomedicine (IRB Barcelona). "Discovery Of A Mechanism That Regulates Cell Movement." ScienceDaily. ScienceDaily, 23 July 2008. <www.sciencedaily.com/releases/2008/07/080720150200.htm>.
Institute for Research in Biomedicine (IRB Barcelona). (2008, July 23). Discovery Of A Mechanism That Regulates Cell Movement. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2008/07/080720150200.htm
Institute for Research in Biomedicine (IRB Barcelona). "Discovery Of A Mechanism That Regulates Cell Movement." ScienceDaily. www.sciencedaily.com/releases/2008/07/080720150200.htm (accessed August 1, 2014).

Share This




More Plants & Animals News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Visitors Feel Part of the Pack at Wolf Preserve

Visitors Feel Part of the Pack at Wolf Preserve

AP (July 31, 2014) — Seacrest Wolf Preserve on the northern Florida panhandle allows more than 10,000 visitors each year to get up close and personal with Arctic and British Columbian Wolves. (July 31) Video provided by AP
Powered by NewsLook.com
Florida Panther Rebound Upsets Ranchers

Florida Panther Rebound Upsets Ranchers

AP (July 31, 2014) — With Florida's panther population rebounding, some ranchers complain the protected predators are once again killing their calves. (July 31) Video provided by AP
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Raw: Thousands Flocking to German Crop Circle

Raw: Thousands Flocking to German Crop Circle

AP (July 30, 2014) — Thousands of people are trekking to a Bavarian farmer's field to check out a mysterious set of crop circles. (July 30) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins